A virus hijacks host cellular machineries and metabolites in order to reproduce. In response,
the innate immune system activates different processes to fight back. Although many aspects …

Translation of an mRNA represents a critical step during the expression of protein-coding
genes. As mechanisms governing post-transcriptional regulation of gene expression are …

Abstract tRNA modifications affect ribosomal elongation speed and co-translational folding
dynamics. The Elongator complex is responsible for introducing 5-carboxymethyl at wobble …

Nitrogen limitation imposes a major transition in the lifestyle of nondiazotrophic
cyanobacteria that is controlled by a complex interplay of regulatory factors involving the …

Abstract Background Neurodevelopmental disorders (NDDs) are heterogeneous,
debilitating conditions that include motor and cognitive disability and social deficits. The …

Intellectual disability (ID) and autism spectrum disorder (ASD) are the most common
neurodevelopmental disorders and are characterized by substantial impairment in …

Pseudouridine (Ψ), the isomer of uridine, is ubiquitously found in RNA, including tRNA,
rRNA, and mRNA. Human pseudouridine synthase 3 (PUS3) catalyzes pseudouridylation of …

Transfer RNA (tRNA) molecules are essential to decode messenger RNA codons during
protein synthesis. All known tRNAs are heavily modified at multiple positions through post …

The eukaryotic multisubunit Elongator complex has been shown to perform multiple
functions in transcriptional elongation, histone acetylation and tRNA modification. However …

Asymmetric cell division gives rise to two daughter cells that inherit different determinants,
thereby acquiring different fates. Polarized trafficking of endosomes containing fate …