The extracellular matrix (ECM) is the complex meshwork of proteins and glycans that forms
the scaffold that surrounds and supports cells. It exerts key roles in all aspects of metazoan …

The completion of the Human Genome Project has provided a foundational blueprint for
understanding human life. Nonetheless, understanding the intricate mechanisms through …

Hundreds of millions of single cells have been analyzed using high-throughput
transcriptomic methods. The cumulative knowledge within these datasets provides an …

Spatial transcriptomics (ST) technologies enable high throughput gene expression
characterization within thin tissue sections. However, comparing spatial observations across …

The ability to localize hundreds of macromolecules to discrete locations, structures and cell
types in a tissue is a powerful approach to understand the cellular and spatial organization …

Follicular lymphoma (FL) is a generally incurable malignancy that evolves from
developmentally blocked germinal center (GC) B cells. To promote survival and immune …

With the convergence in exciting advances in molecular and spatial profiling methods and
new computational approaches leveraging artificial intelligence and machine learning …

Spatial multi-omic studies have emerged as a promising approach to comprehensively
analyze cells in tissues, enabling the joint analysis of multiple data modalities like …

Antigen-specific T cells traffic to, are influenced by, and create unique cellular
microenvironments. Here we characterize these microenvironments over time with …

A cell is a dynamic system in which various processes occur simultaneously. In particular,
intra-and intercellular signaling pathway crosstalk has a significant impact on a cell's life …