Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …

Hyperactivation of the complement and coagulation systems is recognized as part of the
clinical syndrome of COVID-19. Here we review systemic complement activation and local …

The complement system is a recognized pillar of host defence against infection and noxious
self-derived antigens. Complement is traditionally known as a serum-effective system …

The molecular mechanisms governing orderly shutdown and retraction of CD4+ type 1
helper T (TH1) cell responses remain poorly understood. Here we show that complement …

Immunometabolism has emerged as a major mechanism central to adaptive and innate
immune regulation. From early observations that inflammatory cytokines were induced in …

Arthritis typically involves recurrence and progressive worsening at specific predilection
sites, but the checkpoints between remission and persistence remain unknown. Here, we …

The recognition of microbial or danger-associated molecular patterns by complement
proteins initiates a cascade of events that culminates in the activation of surface complement …

Metabolic adaptation to viral infections critically determines the course and manifestations of
disease. At the systemic level, a significant feature of viral infection and inflammation that …

The tumour microenvironment (TME) highly influences the growth and spread of tumours,
thus impacting the patient's clinical outcome. In this context, the complement system plays a …

The complement system is an ancient collection of proteolytic cascades with well-described
roles in regulation of innate and adaptive immunity. With the convergence of a revolution in …