Reductions play a key role in organic synthesis, producing chiral products with new
functionalities. Enzymes can catalyse such reactions with exquisite stereo‐, regio‐and …

Deazaguanine modifications play multifaceted roles in the molecular biology of DNA and
tRNA, sha** diverse yet essential biological processes, including the nuanced fine-tuning …

Biocatalysis is an enabling technology for chemists. Using isolated enzymes or whole cells
gives access to a broad range of selective transformations—often inaccessible with …

Adding value to organic synthesis. Novel imine reductases enable the enantioselective
reduction of imines to afford optically active amines. Likewise, novel bioinspired artificial …

The NADPH-dependent QueF nitrile reductases catalyze the unprecedented four-electron
reduction of nitrile to amine. QueF nitrile reductases can be found in the tRNA biosynthetic …

Reduktionsreaktionen spielen eine zentrale Rolle in der organischen Chemie zur Synthese
chiraler Produkte. Insbesondere Enzyme katalysieren solche Reaktionen in hoher Stereo …

A naturally occurring riboswitch can utilize 7-aminomethyl-O 6-methyl-7-deazaguanine (m 6
preQ 1) as cofactor for methyl group transfer resulting in cytosine methylation. This recently …

Nitrile-containing compounds are widely manufactured and extensively used in the chemical
and pharmaceutical industries as synthetic intermediates or precursors. Nitrile hydratase …

A new route to single‐step and non‐covalent immobilization of proteins on graphene is
exemplified with the first biosensor for nitriles based on a graphene field‐effect transistor …

Abstract The synthesis of 5-hydroxymethyl-, 5-acetoxymethyl-, 5-formyl-and 5-cyanothieno
[2, 3-d] pyrimidines, the (methyl)-5-carboxylate, and the respective amide functionality was …