Peripheral neuropathy in mouse models of diabetes

CG Jolivalt, KE Frizzi, L Guernsey… - Current protocols in …, 2016 - Wiley Online Library
Peripheral neuropathy is a frequent complication of chronic diabetes that most commonly
presents as a distal degenerative polyneuropathy with sensory loss. Around 20% to 30% of …

Methods for evaluating gait associated dynamic balance and coordination in rodents

AD Modi, A Parekh, ZH Patel - Behavioural Brain Research, 2024 - Elsevier
Balance is the dynamic and unconscious control of the body's centre of mass to maintain
postural equilibrium. Regulated by the vestibular system, head movement and acceleration …

Vibrotactile stimulation at gamma frequency mitigates pathology related to neurodegeneration and improves motor function

HJ Suk, N Buie, G Xu, A Banerjee… - Frontiers in Aging …, 2023 - frontiersin.org
The risk for neurodegenerative diseases increases with aging, with various pathological
conditions and functional deficits accompanying these diseases. We have previously …

Innate immunity activation in the early brain injury period following subarachnoid hemorrhage

T Gris, P Laplante, P Thebault, R Cayrol… - Journal of …, 2019 - Springer
Background Aneurysmal subarachnoid hemorrhage (SAH) is a catastrophic disease with
devastating consequences, including a high mortality rate and severe disabilities among …

Motor dysfunction and neurodegeneration in a C9orf72 mouse line expressing poly-PR

Z Hao, L Liu, Z Tao, R Wang, H Ren, H Sun… - Nature …, 2019 - nature.com
A GGGGCC hexanucleotide repeat expansion in intron 1 of chromosome 9 open reading
frame 72 (C9ORF72) gene is the most common genetic cause of amyotrophic lateral …

Subcutaneous rotenone rat model of Parkinson's disease: Dose exploration study

ZN Zhang, JS Zhang, J **ang, ZH Yu, W Zhang, M Cai… - Brain research, 2017 - Elsevier
Subcutaneous administration of rotenone has recently attracted attention because of its
convenience, simplicity and efficacy in replicating features of Parkinson's disease (PD) in …

Phosphorylation of Parkin at serine 65 is essential for its activation in vivo

TG McWilliams, E Barini… - Royal Society …, 2018 - royalsocietypublishing.org
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell
culture and in vitro studies have elaborated the PINK1-dependent regulation of Parkin and …

Telomerase gene therapy ameliorates the effects of neurodegeneration associated to short telomeres in mice

K Whittemore, A Derevyanko, P Martinez… - Aging (Albany …, 2019 - pmc.ncbi.nlm.nih.gov
Neurodegenerative diseases associated with old age such as Alzheimer's disease present
major problems for society, and they currently have no cure. The telomere protective caps at …

Analysis of motor function in the Tg4-42 mouse model of Alzheimer's disease

JM Wagner, ME Sichler, EM Schleicher… - Frontiers in behavioral …, 2019 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder and the most common form of
dementia. Hallmarks of AD are memory impairments and cognitive deficits, but non-cognitive …

Enriched environment decreases microglia and brain macrophages inflammatory phenotypes through adiponectin-dependent mechanisms: Relevance to depressive …

J Chabry, S Nicolas, J Cazareth, E Murris… - Brain, behavior, and …, 2015 - Elsevier
Regulation of neuroinflammation by glial cells plays a major role in the pathophysiology of
major depression. While astrocyte involvement has been well described, the role of …