Human cytomegalovirus (HCMV) is a betaherpesvirus with a global seroprevalence of 60–
90%. HCMV is the leading cause of congenital infections and poses a great health risk to …

The critical role of interferons (IFNs) in mediating the innate immune response to
cytomegalovirus (CMV) infection is well established. However, in recent years the functional …

Membrane contact sites (MCSs) link organelles to coordinate cellular functions across space
and time. Although viruses remodel organelles for their replication cycles, MCSs remain …

Innate immune responses are crucial for limiting virus infection. However, viruses often
hijack our best defenses for viral objectives. Human Cytomegalovirus (HCMV) is a beta …

While many viral infections are limited and eventually resolved by the host immune
response or by death of the host, other viruses establish long-term relationships with the …

Macrophages represent the first line of anti-pathogen defense-they encounter invading
pathogens to perform the phagocytic activity, to deliver the plethora of pro-and anti …

Viral dissemination is a key mechanism responsible for persistence and disease following
human cytomegalovirus (HCMV) infection. Monocytes play a pivotal role in viral …

Introduction Cytomegaloviruses (CMVs) extensively reorganize the membrane system of the
cell and establish a new structure as large as the cell nucleus called the assembly …

Sustained phosphotinositide3-kinase (PI3K) signaling is critical to the maintenance of alpha
and beta herpesvirus latency. We have previously shown that the beta-herpesvirus, human …

Objectives: IgA nephropathy (IgAN) is thought to involve an autoimmune process wherein
galactose-deficient IgA1 (Gd-IgA1), recognized as autoantigen by autoantibodies, forms …