Immune checkpoint blockade (ICB) has revolutionized modern cancer therapy, arousing
great interest in the neuro-oncology community. While several reports show that subsets of …

Gliomas are a diverse group of primary central nervous system tumors that affect both
children and adults. Recent studies have revealed a dynamic cross talk that occurs between …

Given the marginal penetration of most drugs across the blood-brain barrier, the efficacy of
various agents remains limited for glioblastoma (GBM). Here we employ low-intensity pulsed …

The limited efficacy of immunotherapies against glioblastoma underscores the urgency of
better understanding immunity in the central nervous system. We found that treatment with …

Glioblastoma (GBM) tumors consist of multiple cell populations, including self-renewing
glioblastoma stem cells (GSCs) and immunosuppressive microglia. Here we identified …

Glioblastoma is the most common and aggressive primary malignant brain tumour. The
prognosis of patients with glioblastoma is poor, and their overall survival averages at 1 year …

The most widely used fluorophore in glioma-resection surgery, 5-aminolevulinic acid (5-
ALA), is thought to cause the selective accumulation of fluorescent protoporphyrin IX (PpIX) …

Radio-immunotherapy exploits the immunostimulatory features of ionizing radiation (IR) to
enhance antitumor effects and offers emerging opportunities for treating invasive tumor …

With the success of immunotherapy in cancer, understanding the tumor immune
microenvironment (TIME) has become increasingly important; however in pediatric brain …

Whereas the contribution of tumor microenvironment to the profound immune suppression of
glioblastoma (GBM) is clear, tumor-cell intrinsic mechanisms that regulate resistance to CD8 …