Activation of epithelial stem cells and efficient recruitment of their proliferating progeny plays
a critical role in cutaneous wound healing. The reepithelialized wound epidermis has a …

Somatic mutations acquired in healthy tissues as we age are major determinants of cancer
risk. Whether variants confer a fitness advantage or rise to detectable frequencies by chance …

With the capacity for rapid self-renewal and regeneration, the intestinal epithelium is
stereotypical of stem cell–supported tissues. Yet the pattern of stem cell turnover remains in …

For the past 30 years, the prevailing model of epidermal homeostasis has been that
epidermal stem cells give rise to transit amplifying cells, which undergo a limited number of …

The accessibility and transparency of the cornea permit robust stem cell labeling and in vivo
cell fate map**. Limbal epithelial stem cells (LSCs) that renew the cornea are traditionally …

During aging, progenitor cells acquire mutations, which may generate clones that colonize
the surrounding tissue. By middle age, normal human tissues, including the esophageal …

The skin is a classical example of a tissue maintained by stem cells. However, the identity of
the stem cells that maintain the interfollicular epidermis and the source of the signals that …

Diseases of the esophageal epithelium (EE), such as reflux esophagitis and cancer, are
rising in incidence. Despite this, the cellular behaviors underlying EE homeostasis and …

Epithelial lineages have been studied at cellular resolution in multiple organs that turn over
rapidly. However, many epithelia, including those of the lung, liver, pancreas, and prostate …

Typical murine epidermis has a patterned structure, seen clearly in ear skin, with regular
columns of differentiated cells overlying the proliferative basal layer. It has been proposed …