The Keap1-Nrf2 system is an evolutionarily conserved defense mechanism against
oxidative and xenobiotic stress. Its regulatory mechanisms, eg, stress-sensing mechanism …

Senescence is a cellular state linked to ageing and age-onset disease across many
mammalian species,. Acutely, senescent cells promote wound healing, and prevent tumour …

The Nrf2 transcription factor belongs to the Cap'n'collar family, named after the founding
member of this group, the product of the Drosophila Cap'n'collar gene. The encoded protein …

Upon apoptotic stimuli, epithelial cells compensate the gaps left by dead cells by activating
proliferation. This has led to the proposal that dying cells signal to surrounding living cells to …

Macrophages are multifunctional cells that perform diverse roles in health and disease.
Emerging evidence has suggested that these innate immune cells might also be capable of …

JNK signaling is a critical regulator of inflammation and regeneration, but how it is controlled
in specific tissue contexts remains unclear. Here we show that, in the Drosophila intestine …

The brain has a limited capacity to self-protect against protein aggregate-associated
pathology, and mounting evidence supports a role for phagocytic glia in this process. We …

Many organisms lose the capacity to regenerate damaged tissues as they mature. Damaged
Drosophila imaginal discs regenerate efficiently early in the third larval instar (L3) but …

Cell competition is a form of cell interaction that causes the elimination of less fit cells, or
losers, by wild-type (WT) cells, influencing overall tissue health. Several mutations can …

Epithelial repair relies on the activation of stress signaling pathways to coordinate tissue
repair. Their deregulation is implicated in chronic wound and cancer pathologies. Using TNF …