Conspectus This Account describes the manner whereby nature controls the Fenton-type
reaction of O–O homolysis of hydrogen peroxide and harnesses it to carry out various useful …

Nonheme iron-dependent enzymatic reactions play crucial roles in building and modifying
bioactive organic molecules in all major classes of natural product pathways. While the …

Epoxides, aziridines, and cyclopropanes are found in various medicinal natural products,
including polyketides, terpenes, peptides, and alkaloids. Many classes of biosynthetic …

Understanding the molecular basis for controlled H2O2 activation is of fundamental
importance for peroxide-driven catalysis by metalloenzymes. In addition to O2 activation in …

Non-heme iron enzymes are versatile catalysts in the biosynthesis of medicinal natural
products and have attracted increasing attention as practical catalytic tools in chemical …

The ability to introduce noncanonical amino acids as axial ligands in heme enzymes has
provided a powerful experimental tool for studying the structure and reactivity of their FeIV═ …

The phosphonate class of natural products have received significant interests in the post-
genomic era due to the relative ease with which their biosynthetic genes may be identified …

The fungal metabolite Fosfonochlorin features a chloroacetyl moiety that is unusual within
known phosphonate natural product biochemistry. Putative biosynthetic genes encoding …

The combined molecular dynamics (MD) simulations and quantum mechanical/molecular
mechanics (QM/MM) calculations have been performed to address the longstanding issue of …

Organophosphonates (Pns) are a unique class of natural products characterized by a highly
stable C–P bond. Pns exhibit a wide array of interesting structures as well as useful …