In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …

Cervical cancer develops through persistent infection with high-risk human papilloma virus
(hrHPV) and is a leading cause of death among women worldwide and in the United States …

Growing evidence suggests that aberrant epigenetic regulation of gene function is strongly
related to the genesis of cancer. Unlike genetic mutations, the ability to reprogram the …

As one of the most abundant and well-studied epigenetic modifications, DNA methylation
plays an essential role in normal development and cellular biology. Global alterations to the …

Adipocytes are critical for ovarian cancer cells to home to the omentum, but the metabolic
changes initiated by this interaction are unknown. To this end, we carried out unbiased mass …

Hydroxymethylcytosine (hmC) is an oxidation product of 5-methylcytosine which is present
in the deoxyribonucleic acid (DNA) of most mammalian cells. Reduction of hmC levels in …

DNA methylation provides a pivotal layer of epigenetic regulation in eukaryotes that has
significant involvement for numerous biological processes in health and disease. The …

DNA methylation at the 5 position of cytosine (5-mC) is a key epigenetic mark that is critical
for various biological and pathological processes. 5-mC can be converted to 5 …

Carcinogenesis involves uncontrolled cell growth, which follows the activation of oncogenes
and/or the deactivation of tumor suppression genes. Metastasis requires down-regulation of …

Loss-of-function mutations in genes encoding TET DNA dioxygenase occur frequently in
hematopoietic malignancy, but rarely in solid tumors, which instead commonly have reduced …