Immune checkpoint therapy—current perspectives and future directions
Immune checkpoint therapy (ICT) has dramatically altered clinical outcomes for cancer
patients and conferred durable clinical benefits, including cure in a subset of patients …
patients and conferred durable clinical benefits, including cure in a subset of patients …
How chemokines organize the tumour microenvironment
For our immune system to contain or eliminate malignant solid tumours, both myeloid and
lymphoid haematopoietic cells must not only extravasate from the bloodstream into the …
lymphoid haematopoietic cells must not only extravasate from the bloodstream into the …
[HTML][HTML] Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution
Tumor evolution is driven by the progressive acquisition of genetic and epigenetic
alterations that enable uncontrolled growth and expansion to neighboring and distal tissues …
alterations that enable uncontrolled growth and expansion to neighboring and distal tissues …
[HTML][HTML] Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer
TH 2 cells and innate lymphoid cells 2 (ILC2) can stimulate tumor growth by secreting pro-
tumorigenic cytokines such as interleukin-4 (IL-4), IL-5, and IL-13. However, the …
tumorigenic cytokines such as interleukin-4 (IL-4), IL-5, and IL-13. However, the …
Localization, tissue biology and T cell state—implications for cancer immunotherapy
Tissue localization is a critical determinant of T cell immunity. CD8+ T cells are contact-
dependent killers, which requires them to physically be within the tissue of interest to kill …
dependent killers, which requires them to physically be within the tissue of interest to kill …
Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects
C Li, P Jiang, S Wei, X Xu, J Wang - Molecular cancer, 2020 - Springer
Regulatory T cells (Tregs) characterized by the expression of the master transcription factor
forkhead box protein p3 (Foxp3) suppress anticancer immunity, thereby hindering protective …
forkhead box protein p3 (Foxp3) suppress anticancer immunity, thereby hindering protective …
[HTML][HTML] Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer
Local environmental factors influence CD8+ T cell priming in lymph nodes (LNs). Here, we
sought to understand how factors unique to the tumor-draining mediastinal LN (mLN) impact …
sought to understand how factors unique to the tumor-draining mediastinal LN (mLN) impact …
[HTML][HTML] Conventional type I dendritic cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+ CD8+ T cells in tumor-draining lymph nodes
In tumors, a subset of CD8+ T cells expressing the transcription factor TCF-1 drives the
response to immune checkpoint blockade. We examined the mechanisms that maintain …
response to immune checkpoint blockade. We examined the mechanisms that maintain …
Gasdermin D–mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma
R Yamagishi, F Kamachi, M Nakamura… - Science …, 2022 - science.org
Long-term senescent cells exhibit a secretome termed the senescence-associated secretory
phenotype (SASP). Although the mechanisms of SASP factor induction have been …
phenotype (SASP). Although the mechanisms of SASP factor induction have been …
Tissue regulatory T cells: regulatory chameleons
AR Muñoz-Rojas, D Mathis - Nature Reviews Immunology, 2021 - nature.com
Abstract The FOXP3+ CD4+ regulatory T (Treg) cells located in non-lymphoid tissues differ
in phenotype and function from their lymphoid organ counterparts. Tissue Treg cells have …
in phenotype and function from their lymphoid organ counterparts. Tissue Treg cells have …