Matrix Metalloproteinases: A challenging paradigm of cancer management
Matrix metalloproteinases (MMPs) are members of zinc-dependent endopeptidases
implicated in a variety of physiological and pathological processes. Over the decades …
implicated in a variety of physiological and pathological processes. Over the decades …
[PDF][PDF] Reactive oxygen species in tumor progression
P Storz - Front biosci, 2005 - researchgate.net
Introduction 3. Reactive oxygen species in tumor growth and cellular survival 4. Reactive
oxygen species in cell motility and metastasis formation 5. Generation of reactive oxygen …
oxygen species in cell motility and metastasis formation 5. Generation of reactive oxygen …
Matrix metalloproteinases: their functional role in lung cancer
Lung malignancy is the foremost cause of cancer-related deaths globally and is frequently
related to long-term tobacco smoking. Recent studies reveal that the expression of matrix …
related to long-term tobacco smoking. Recent studies reveal that the expression of matrix …
Mitochondrial redox control of matrix metalloproteinases
KK Nelson, JA Melendez - Free Radical Biology and Medicine, 2004 - Elsevier
Reactive oxygen species (ROS) are constantly generated in aerobic organisms during
normal metabolism and in response to both internal and external stimuli. Imbalances in the …
normal metabolism and in response to both internal and external stimuli. Imbalances in the …
Tumour-stroma interaction: cancer-associated fibroblasts as novel targets in anti-cancer therapy?
P Micke - Lung cancer, 2004 - Elsevier
Stroma cells, together with extracellular matrix components, provide the microenvironment
that is pivotal for cancer cell growth, invasion and metastatic progression. Characteristic …
that is pivotal for cancer cell growth, invasion and metastatic progression. Characteristic …
Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in the respiratory tract: potential implications in asthma and other lung diseases
In healthy lung, Matrix Metalloproteinases (MMPs) and their physiological inhibitors, tissue
inhibitors of matrix metalloproteinases (TIMPs), are produced in the respiratory tract by a …
inhibitors of matrix metalloproteinases (TIMPs), are produced in the respiratory tract by a …
Matrix metalloproteinases in lung diseases
H Ohbayashi - Current Protein and Peptide Science, 2002 - ingentaconnect.com
Matrix metalloproteinases (MMPs) are a pivotal family of zinc enzymes responsible for
degradation of the extracellular matrix (ECM) components including basement membrane …
degradation of the extracellular matrix (ECM) components including basement membrane …
Phase III study of matrix metalloproteinase inhibitor prinomastat in non–small-cell lung cancer
D Bissett, KJ O'Byrne, J Von Pawel… - Journal of Clinical …, 2005 - ascopubs.org
Purpose Matrix metalloproteinases (MMPs) degrade extracellular proteins and facilitate
tumor growth, invasion, metastasis, and angiogenesis. This trial was undertaken to …
tumor growth, invasion, metastasis, and angiogenesis. This trial was undertaken to …
Prospective, randomized, double-blind, placebo-controlled trial of marimastat after response to first-line chemotherapy in patients with small-cell lung cancer: a trial of …
PURPOSE: Increased expression of metalloproteinases is associated with poor prognosis in
small-cell lung cancer (SCLC). This trial was undertaken to determine whether adjuvant …
small-cell lung cancer (SCLC). This trial was undertaken to determine whether adjuvant …
Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model
Lung cancer is one of the leading cancer malignancies, with a five-year survival rate of
only∼ 15%. We have developed a lentiviral-vector-mediated mouse model, which enables …
only∼ 15%. We have developed a lentiviral-vector-mediated mouse model, which enables …