Ewing's sarcoma family of tumors: current management
Abstract Learning Objectives After completing this course, the reader will be able to:
Describe the presentation, differential diagnosis, and prognosis for patients with Ewing's …
Describe the presentation, differential diagnosis, and prognosis for patients with Ewing's …
Updates on cytogenetics and molecular genetics of bone and soft tissue tumors:: Ewing sarcoma and peripheral primitive neuroectodermal tumors
AA Sandberg, JA Bridge - Cancer genetics and cytogenetics, 2000 - Elsevier
Cytogenetics of Bone and Soft Tissue Tumors [1]. In view of the remarkable developments in
this field since 1994, both in the cytogenetic and particularly in the molecular genetic …
this field since 1994, both in the cytogenetic and particularly in the molecular genetic …
Genomic Landscape of Ewing Sarcoma Defines an Aggressive Subtype with Co-Association of STAG2 and TP53 Mutations
Ewing sarcoma is a primary bone tumor initiated by EWSR1–ETS gene fusions. To identify
secondary genetic lesions that contribute to tumor progression, we performed whole …
secondary genetic lesions that contribute to tumor progression, we performed whole …
The genomic landscape of pediatric Ewing sarcoma
Pediatric Ewing sarcoma is characterized by the expression of chimeric fusions of EWS and
ETS family transcription factors, representing a paradigm for studying cancers driven by …
ETS family transcription factors, representing a paradigm for studying cancers driven by …
The Genomic Landscape of the Ewing Sarcoma Family of Tumors Reveals Recurrent STAG2 Mutation
The Ewing sarcoma family of tumors (EFT) is a group of highly malignant small round blue
cell tumors occurring in children and young adults. We report here the largest genomic …
cell tumors occurring in children and young adults. We report here the largest genomic …
The INK4A/ARF locus and its two gene products
The INK4A/ARF locus on chromosome 9 is one of the sites mutated most frequently in
human cancer. Two genes comprising overlap** reading frames encoding p16INK4a and …
human cancer. Two genes comprising overlap** reading frames encoding p16INK4a and …
Homozygous Deletion of CDKN2A and Codeletion of the Methylthioadenosine Phosphorylase Gene in the Majority of Pleural Mesotheliomas
Purpose: Homozygous deletions at chromosome region 9p21 targeting the CDKN2A gene
have been reported as a common cytogenetic abnormality in mesothelioma. MTAP, a …
have been reported as a common cytogenetic abnormality in mesothelioma. MTAP, a …
EWS-FLI-1 expression triggers a Ewing's sarcoma initiation program in primary human mesenchymal stem cells
Ewing's sarcoma family tumors (ESFT) express the EWS-FLI-1 fusion gene generated by the
chromosomal translocation t (11; 22)(q24; q12). Expression of the EWS-FLI-1 fusion protein …
chromosomal translocation t (11; 22)(q24; q12). Expression of the EWS-FLI-1 fusion protein …
STAG2 mutations alter CTCF-anchored loop extrusion, reduce cis-regulatory interactions and EWSR1-FLI1 activity in Ewing sarcoma
D Surdez, S Zaidi, S Grossetête, K Laud-Duval… - Cancer cell, 2021 - cell.com
STAG2, a cohesin family gene, is among the most recurrently mutated genes in cancer.
STAG2 loss of function (LOF) is associated with aggressive behavior in Ewing sarcoma, a …
STAG2 loss of function (LOF) is associated with aggressive behavior in Ewing sarcoma, a …
Molecular biology of the Ewing's sarcoma/primitive neuroectodermal tumor family
E de Alava, WL Gerald - Journal of Clinical Oncology, 2000 - ascopubs.org
Ewing's sarcoma (ES) and primitive neuroectodermal tumor (PNET) are members of a tumor
family consistently associated with chromosomal translocation and functional fusion of the …
family consistently associated with chromosomal translocation and functional fusion of the …