A systematic review of the protective effects of silymarin/silibinin against doxorubicin-induced cardiotoxicity

M Singh, MM Kadhim, A Turki Jalil, SK Oudah… - Cancer Cell …, 2023 - Springer
Purpose Although doxorubicin chemotherapy is commonly applied for treating different
malignant tumors, cardiotoxicity induced by this chemotherapeutic agent restricts its clinical …

Formulation strategies for enhancing the bioavailability of silymarin: the state of the art

A Di Costanzo, R Angelico - Molecules, 2019 - mdpi.com
Silymarin, a mixture of flavonolignan and flavonoid polyphenolic compounds extractable
from milk thistle (Silybum marianum) seeds, has anti-oxidant, anti-inflammatory, anti-cancer …

Lipid-based delivery systems for flavonoids and flavonolignans: liposomes, nanoemulsions, and solid lipid nanoparticles

S Ranjbar, A Emamjomeh, F Sharifi, A Zarepour… - Pharmaceutics, 2023 - mdpi.com
Herbal chemicals with a long history in medicine have attracted a lot of attention.
Flavonolignans and flavonoids are considered as two classes of the above-mentioned …

Nanodrugs with intrinsic radioprotective exertion: Turning the double‐edged sword into a single‐edged knife

J Guo, Z Zhao, ZF Shang, Z Tang, H Zhu, K Zhang - Exploration, 2023 - Wiley Online Library
Ionizing radiation (IR) poses a growing threat to human health, and thus ideal
radioprotectors with high efficacy and low toxicity still receive widespread attention in …

[HTML][HTML] The promising future of nano-antioxidant therapy against environmental pollutants induced-toxicities

A Eftekhari, SM Dizaj, L Chodari, S Sunar… - Biomedicine & …, 2018 - Elsevier
Developmental toxicity caused by exposure to a mixture of environmental pollutants has
become a major health concern. Human-made chemicals, including xenoestrogens …

Cold atmospheric plasma induces apoptosis in human colon and lung cancer cells through modulating mitochondrial pathway

Y Wang, X Mang, X Li, Z Cai, F Tan - Frontiers in Cell and …, 2022 - frontiersin.org
Cold atmospheric plasma (CAP) is an emerging and promising oncotherapy with
considerable potential and advantages that traditional treatment modalities lack. The …

Silymarin: Not just another antioxidant

FC Camini, DC Costa - Journal of basic and clinical physiology and …, 2020 - degruyter.com
Abstract Silymarin (Silybum marianum; SM), popularly known as milk thistle, is an extract
that has been used for many centuries to treat liver diseases. In recent years, several studies …

Cold atmospheric plasma and silymarin nanoemulsion synergistically inhibits human melanoma tumorigenesis via targeting HGF/c-MET downstream pathway

M Adhikari, N Kaushik, B Ghimire, B Adhikari… - Cell Communication and …, 2019 - Springer
Background Recent studies claimed the important role of cold atmospheric plasma (CAP)
with nanotechnology in cancer treatments. In this study, silymarin nanoemulsion (SN) was …

Application of multifunctional nanomaterials in radioprotection of healthy tissues

J **e, C Wang, F Zhao, Z Gu… - Advanced healthcare …, 2018 - Wiley Online Library
Radiotherapy has been extensively used in clinic for malignant tumors treatment. However,
a severe challenge of it is that the ionizing radiation needed to kill tumors inevitably causes …

Silymarin nanoemulsion against human hepatocellular carcinoma: development and optimization

U Ahmad, J Akhtar, SP Singh, Badruddeen… - Artificial cells …, 2018 - Taylor & Francis
Objective: Nanoemulsion of silymarin was developed and optimized. Materials and
methods: Nanoemulsion was made by aqueous titration method. Sefsol 218 (5.8% v/v) …