Drug–target interaction prediction: databases, web servers and computational models
Identification of drug–target interactions is an important process in drug discovery. Although
high-throughput screening and other biological assays are becoming available …
high-throughput screening and other biological assays are becoming available …
Machine learning for drug-target interaction prediction
Identifying drug-target interactions will greatly narrow down the scope of search of candidate
medications, and thus can serve as the vital first step in drug discovery. Considering that in …
medications, and thus can serve as the vital first step in drug discovery. Considering that in …
The Drug Repurposing Hub: a next-generation drug library and information resource
CORRESPONDENCE (tool compounds are valuable for achieving the target redundancy
needed to differentiate on-target from off-target activities of clinical drugs being considered …
needed to differentiate on-target from off-target activities of clinical drugs being considered …
The BioGRID interaction database: 2017 update
A Chatr-Aryamontri, R Oughtred, L Boucher… - Nucleic acids …, 2017 - academic.oup.com
Abstract The Biological General Repository for Interaction Datasets (BioGRID:
https://thebiogrid. org) is an open access database dedicated to the annotation and archival …
https://thebiogrid. org) is an open access database dedicated to the annotation and archival …
Therapeutic target database update 2018: enriched resource for facilitating bench-to-clinic research of targeted therapeutics
Extensive efforts have been directed at the discovery, investigation and clinical monitoring of
targeted therapeutics. These efforts may be facilitated by the convenient access of the …
targeted therapeutics. These efforts may be facilitated by the convenient access of the …
RASTtk: A modular and extensible implementation of the RAST algorithm for building custom annotation pipelines and annotating batches of genomes
Abstract The RAST (Rapid Annotation using Subsystem Technology) annotation engine was
built in 2008 to annotate bacterial and archaeal genomes. It works by offering a standard …
built in 2008 to annotate bacterial and archaeal genomes. It works by offering a standard …
Understanding multicellular function and disease with human tissue-specific networks
Tissue and cell-type identity lie at the core of human physiology and disease. Understanding
the genetic underpinnings of complex tissues and individual cell lineages is crucial for …
the genetic underpinnings of complex tissues and individual cell lineages is crucial for …
DSigDB: drug signatures database for gene set analysis
We report the creation of Drug Signatures Database (DSigDB), a new gene set resource that
relates drugs/compounds and their target genes, for gene set enrichment analysis (GSEA) …
relates drugs/compounds and their target genes, for gene set enrichment analysis (GSEA) …
WITHDRAWN—a resource for withdrawn and discontinued drugs
VB Siramshetty, J Nickel, C Omieczynski… - Nucleic acids …, 2016 - academic.oup.com
Post-marketing drug withdrawals can be associated with various events, ranging from safety
issues such as reported deaths or severe side-effects, to a multitude of non-safety problems …
issues such as reported deaths or severe side-effects, to a multitude of non-safety problems …
[HTML][HTML] A comprehensive review of feature based methods for drug target interaction prediction
Drug target interaction is a prominent research area in the field of drug discovery. It refers to
the recognition of interactions between chemical compounds and the protein targets in the …
the recognition of interactions between chemical compounds and the protein targets in the …