NK cell recognition
LL Lanier - Annu. Rev. Immunol., 2005 - annualreviews.org
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KIR: diverse, rapidly evolving receptors of innate and adaptive immunity
C Vilches, P Parham - Annual review of immunology, 2002 - annualreviews.org
KIR genes have evolved in primates to generate a diverse family of receptors with unique
structures that enable them to recognize MHC-class I molecules with locus and allele …
structures that enable them to recognize MHC-class I molecules with locus and allele …
NK cells switch from granzyme B to death receptor–mediated cytotoxicity during serial killing
I Prager, C Liesche, H Van Ooijen, D Urlaub… - Journal of Experimental …, 2019 - rupress.org
NK cells eliminate virus-infected and tumor cells by releasing cytotoxic granules containing
granzyme B (GrzB) or by engaging death receptors that initiate caspase cascades. The …
granzyme B (GrzB) or by engaging death receptors that initiate caspase cascades. The …
Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells
O Mandelboim, N Lieberman, M Lev, L Paul, TI Arnon… - Nature, 2001 - nature.com
Natural killer (NK) cells destroy virus-infected and tumour cells, apparently without the need
for previous antigen stimulation. In part, target cells are recognized by their diminished …
for previous antigen stimulation. In part, target cells are recognized by their diminished …
MUC16 (CA125): tumor biomarker to cancer therapy, a work in progress
M Felder, A Kapur, J Gonzalez-Bosquet, S Horibata… - Molecular cancer, 2014 - Springer
Over three decades have passed since the first report on the expression of CA125 by
ovarian tumors. Since that time our understanding of ovarian cancer biology has changed …
ovarian tumors. Since that time our understanding of ovarian cancer biology has changed …
The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal
J Lieberman - Nature Reviews Immunology, 2003 - nature.com
Granule exocytosis is the main pathway for the immune elimination of virus-infected cells
and tumour cells by cytotoxic T lymphocytes and natural killer cells. After target-cell …
and tumour cells by cytotoxic T lymphocytes and natural killer cells. After target-cell …
Tumors evade immune cytotoxicity by altering the surface topology of NK cells
X Zheng, Z Hou, Y Qian, Y Zhang, Q Cui, X Wang… - Nature …, 2023 - nature.com
The highly variable response rates to immunotherapies underscore our limited knowledge
about how tumors can manipulate immune cells. Here the membrane topology of natural …
about how tumors can manipulate immune cells. Here the membrane topology of natural …
The immunological synapse
SK Bromley, WR Burack, KG Johnson… - Annual review of …, 2001 - annualreviews.org
The adaptive immune response is initiated by the interaction of T cell antigen receptors with
major histocompatibility complex molecule-peptide complexes in the nanometer scale gap …
major histocompatibility complex molecule-peptide complexes in the nanometer scale gap …
[HTML][HTML] The immunological synapse of CTL contains a secretory domain and membrane bridges
JC Stinchcombe, G Bossi, S Booth, GM Griffiths - Immunity, 2001 - cell.com
Cytotoxic T lymphocytes (CTL) rapidly destroy their targets. Here we show that although
target cell death occurs within 5 min of CTL-target cell contact, an immunological synapse …
target cell death occurs within 5 min of CTL-target cell contact, an immunological synapse …
Polymer micropatches as natural killer cell engagers for tumor therapy
Natural killer (NK) cell therapies have emerged as a potential therapeutic approach to
various cancers. Their efficacy, however, is limited by their low persistence and anergy …
various cancers. Their efficacy, however, is limited by their low persistence and anergy …