The brain extracellular space (ECS) is a vast interstitial reticulum of extreme morphological
complexity, composed of narrow gaps separated by local expansions, enabling …

Inherent limitations of the traditional approaches to study brain function and disease, such
as rodent models and 2D cell culture platforms, have led to the development of 3D in vitro …

STED microscopy is one of several fluorescence microscopy techniques that permit imaging
at higher spatial resolution than what the diffraction-limit of light dictates. STED imaging is …

Lewy body disorders are heterogeneous neurological conditions defined by intracellular
inclusions composed of misshapen α-synuclein protein aggregates. Although α-synuclein …

Parkinson's disease (PD) is pathologically characterized by intracellular α-synuclein-rich
protein aggregates, named Lewy bodies (LB), and by the progressive loss of dopaminergic …

The development and survival of dopaminergic neurons are influenced by the fibroblast
growth factor (FGF) pathway. Anosmin-1 (A1) is an extracellular matrix protein that acts as a …

Synapse dysfunction has been definitively linked to cognitive impairments in the aging brain,
and microglial physiology has emerged as a robust regulator of synapse status and …

Understanding how neurons develop to form the organized pattern of synaptic connections
remains a central question in neuroscience. The vast majority of excitatory synapses are …

The N-methyl-D-aspartate receptor (NMDAR) plays a pivotal role in both health anddisease,
serving as a crucial mediator of synaptic plasticity and memory while also being implicated …