The two biggest success stories in allergy treatment are topical glucocorticosteroids and
allergen immunotherapy (AIT). Glucocorticosteroids, the principal pharmaceuticals of allergy …

Since the discovery that IgE antibodies mediate allergy, decades of research have
unraveled complex mechanisms associated with conventional immunotherapy and the vital …

Background Peanut allergy is a severe and increasingly frequent disease with high medical,
psychosocial, and economic burden for affected patients and wider society. A causal, safe …

Background House dust mites (HDMs) are among the most important allergen sources
containing many different allergenic molecules. Analysis of patients from a double-blind …

Background Allergy to peanut is one of the leading causes of anaphylactic reactions among
food allergic patients. Immunization against peanut allergy with a safe and protective …

Peanut allergy can result in life-threatening reactions and is a major public health concern.
Oral immunotherapy (OIT) induces desensitization to food allergens through administration …

Background Cat allergy in human subjects is usually caused by the major cat allergen Fel d
1 and is found in approximately 10% of the Western population. Currently, there is no …

Mechanisms linking intestinal bacteria and neurodegenerative diseases such as
Alzheimer's disease (AD) are still unclear. We hypothesized that intestinal dysbiosis might …

Successful treatment of IgE mediated allergies by allergen-specific immunotherapy (AIT)
usually correlates with the induction of allergen-specific IgG4. However, it is not clear …

Background Type I hypersensitivity is mediated by allergen-specific IgE, which sensitizes the
high-affinity IgE receptor FcεRI on mast cells and basophils and drives allergic inflammation …