LC-MS method development for the quantitation of potential genotoxic impurity 2-Methyl-6-nitro...

Evaluation, method development, and validation for content determination of potential genotoxic impurities (PGIs) at the TTC level in Telmisartan API

S Patil, K Patel, R Chadar, S Ramar… - … Process Research & …, 2021 - ACS Publications
Telmisartan is an angiotensin II receptor antagonist used in the cure of hypertension and
other heart diseases. In the current research work, the synthetic route of Telmisartan …
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Development and validation of sensitive high‐performance liquid chromatography‐photodiode array method for determination of three sulfonated esters and N‐methyl …

L Chenkual, DS Lalchandani… - Separation …, 2023 - Wiley Online Library
Several regulatory organizations encourage the quantitative analysis of potentially
genotoxic impurities in finished pharmaceutical preparation. For the first time, a sensitive …
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[PDF][PDF] A Simple and Sensitive LC-MS/MS Method for Determination and Quantification of Potential Genotoxic Impurities in the Vismodegib Active Pharmaceutical …

RR Rao, GR Kumar, VM Vardhan, V Boddu - International, 2021 - researchgate.net
ABSTRACT A rapid and sensitive LC-tandem mass spectrometry (LC-MS/MS) method was
developed and validated for the quantitative analysis of four potential genotoxic impurities …
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[PDF][PDF] A REVIEW ON ANALYTICAL CHALLENGES IN MONITORING AND CONTROLLING GENOTOXIC IMPURITIES

SS VANDAMME, K SELVAKUMAR… - Asian J Pharm Clin …, 2020 - researchgate.net
Genotoxic impurities (GIs) are chemical agents that have a DNA-interaction characteristic
which can ultimately lead to cancer. Their presence in various drug substances had driven …
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[PDF][PDF] Low Level Quantification of Potential Genotoxic Impurities In Telmisartan Drug Substance by HPLC

K Srivalli, N Annapurna, KR Babu, C Ramdas… - researchgate.net
ABSTRACT A sensitive and rapid HPLC method was developed and validated for the
determination of potential genotoxic impurities ie(Bromomethyl) biphenyl methyl ester and …
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