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IgA nephropathy
IgA nephropathy (IgAN), the most prevalent primary glomerulonephritis worldwide, carries a
considerable lifetime risk of kidney failure. Clinical manifestations of IgAN vary from …
considerable lifetime risk of kidney failure. Clinical manifestations of IgAN vary from …
IgA nephropathy
Abstract Globally, IgA nephropathy (IgAN) is the most common primary glomerulonephritis
that can progress to renal failure. The exact pathogenesis of IgAN is not well defined, but …
that can progress to renal failure. The exact pathogenesis of IgAN is not well defined, but …
A phase 2 trial of sibeprenlimab in patients with IgA nephropathy
Background A proliferation-inducing ligand (APRIL) is implicated in the pathogenesis of IgA
nephropathy. Sibeprenlimab is a humanized IgG2 monoclonal antibody that binds to and …
nephropathy. Sibeprenlimab is a humanized IgG2 monoclonal antibody that binds to and …
Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy
IgA nephropathy (IgAN) is a progressive form of kidney disease defined by glomerular
deposition of IgA. Here we performed a genome-wide association study of 10,146 kidney …
deposition of IgA. Here we performed a genome-wide association study of 10,146 kidney …
Efficacy and safety of a targeted-release formulation of budesonide in patients with primary IgA nephropathy (NefIgArd): 2-year results from a randomised phase 3 trial
R Lafayette, J Kristensen, A Stone, J Floege, V Tesař… - The Lancet, 2023 - thelancet.com
Background IgA nephropathy is a chronic immune-mediated kidney disease and a major
cause of kidney failure worldwide. The gut mucosal immune system is implicated in its …
cause of kidney failure worldwide. The gut mucosal immune system is implicated in its …
Complement, a target for therapy in inflammatory and degenerative diseases
The complement system is a key innate immune defence against infection and an important
driver of inflammation; however, these very properties can also cause harm. Inappropriate or …
driver of inflammation; however, these very properties can also cause harm. Inappropriate or …
NF-κB in inflammation and renal diseases
H Zhang, SC Sun - Cell & bioscience, 2015 - Springer
Nuclear factor κB (NF-κB) is a family of inducible transcription factors that plays a vital role in
different aspects of immune responses. NF-κB is normally sequestered in the cytoplasm as …
different aspects of immune responses. NF-κB is normally sequestered in the cytoplasm as …
[HTML][HTML] Safety, tolerability and efficacy of narsoplimab, a novel MASP-2 inhibitor for the treatment of IgA nephropathy
RA Lafayette, BH Rovin, HN Reich, JA Tumlin… - Kidney international …, 2020 - Elsevier
Introduction Narsoplimab is a human monoclonal antibody against mannan-associated
lectin-binding serine protease− 2 (MASP-2). Now in a phase 3 study, narsoplimab was …
lectin-binding serine protease− 2 (MASP-2). Now in a phase 3 study, narsoplimab was …
[HTML][HTML] New developments in the genetics, pathogenesis, and therapy of IgA nephropathy
Recent years have brought notable progress in the field of IgA nephropathy. Here, we
highlight important new directions and latest developments, including successful discovery …
highlight important new directions and latest developments, including successful discovery …
Current understanding of the role of complement in IgA nephropathy
Complement activation has a role in the pathogenesis of IgA nephropathy, an autoimmune
disease mediated by pathogenic immune complexes consisting of galactose-deficient IgA1 …
disease mediated by pathogenic immune complexes consisting of galactose-deficient IgA1 …