Efficient viral gene expression is threatened by cellular stress response programmes that
rapidly reprioritize the translation machinery in response to varied environmental assaults …

DEAD-box helicases are a large family of conserved RNA-binding proteins that belong to
the broader group of cellular DExD/H helicases. Members of the DEAD-box helicase family …

Double-stranded RNA produced during viral replication and transcription activates both
protein kinase R (PKR) and ribonuclease L (RNase L), which limits viral gene expression …

Cellular heterogeneity within the mammalian brain poses a challenge toward understanding
its complex functions. Within the olfactory bulb, odor information is processed by subtypes of …

The nucleus represents a cellular compartment where the discrimination of self from non-self
nucleic acids is vital. While emerging evidence establishes a nuclear non-self DNA sensing …

Virus infection leads to activation of the interferon (IFN)-induced endoribonuclease RNase L,
which results in degradation of viral and cellular RNAs. Both cellular and viral RNA cleavage …

The innate immune response to viruses is critical for the correct establishment of protective
adaptive immunity. Amongst the many pathways involved, the NLRP3 [nucleotide-binding …

Viruses and hosts have coevolved for millions of years, leading to the development of
complex host–pathogen interactions. Influenza A virus (IAV) causes severe pulmonary …

Porcine epidemic diarrhea virus (PEDV) is an α-coronavirus causing severe diarrhea and
high mortality rates in suckling piglets and posing significant economic impact. PEDV …

ABSTRACT RNA helicases are integral in RNA metabolism, performing important roles in
cellular homeostasis and stress responses. In particular, the DExD/H-box (DDX) helicase …