Background Excessive exposure of the skin to UV radiation (UVR) triggers a remodeling of
the immune system and leads to the photoaging state which is reminiscent of chronological …

Most older individuals develop inflammageing, a condition characterized by elevated levels
of blood inflammatory markers that carries high susceptibility to chronic morbidity, disability …

Background The increasing numbers of people living with HIV (PLHIV) who are receiving
antiretroviral therapy (ART) have near normal life-expectancy, resulting in more people …

The aging process is driven by a finite number of inter‐related mechanisms that ultimately
lead to the emergence of characteristic phenotypes, including increased susceptibility to …

Systemic inflammation in end-stage renal disease is an established risk factor for mortality
and a catalyst for other complications, which are related to a premature aging phenotype …

Chronic immune activation has a significant role in HIV-1 disease pathogenesis and CD4+ T-
cell depletion. The causes of chronic inflammation and immune activation are incompletely …

Mitochondria are intracellular organelles involved in a myriad of activities. To safeguard their
vital functions, mitochondrial quality control (MQC) systems are in place to support organelle …

People living with HIV (PLWH) experience increased vulnerability to premature aging and
inflammation-associated comorbidities, even when HIV replication is suppressed by …

The increased prevalence of age-related comorbidities and mortality is worrisome in ageing
HIV-infected patients. Here, we aim to analyse the different ageing mechanisms with regard …

The aging process is associated with a remodeling of the immune system involving chronic
low-grade inflammation and a gradual decline in the function of the immune system. These …