Neurodegenerative diseases are a set of progressive and currently incurable diseases that
are primarily caused by neuron degeneration. Neurodegenerative diseases often lead to …

Endocytosis in mammalian cells is a fundamental cellular machinery that regulates vital
physiological processes, such as the absorption of metabolites, release of neurotransmitters …

Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common
neurodegenerative diseases (NDDs) threatening the lives of millions of people worldwide …

Parkinson's disease (PD) is a widespread neurodegenerative disorder occurs due to the
degradation of dopaminergic neurons present in the substantia nigra pars compacta (SNpc) …

Parkinson's disease (PD) is a predominantly idiopathic pathological condition characterized
by protein aggregation phenomena, whose main component is alpha-synuclein. Although …

The detection of early molecular mechanisms and potential biomarkers in Parkinson's
disease (PD) remains a challenge. Recent research has pointed to novel roles for post …

Efficient signal transduction is important in maintaining the function of the nervous system
across tissues. An intact neurotransmission process can regulate energy balance through …

Mutations in the GBA1 gene represent the major genetic risk factor for Parkinson's disease
(PD). The lysosomal enzyme beta-glucocerebrosidase (GCase) encoded by the GBA1 gene …

The widely-accepted hallmark pathology of Parkinson's disease (PD) is the presence of
Lewy bodies with characteristic abnormal aggregated α-synuclein (αSyn). Growing …

The origins of Alzheimer's disease (AD) and Parkinson's disease (PD) involve genetic
mutations, epigenetic changes, neurotoxin exposure and gut microbiota dysregulation. The …