Recent progress of SELEX methods for screening nucleic acid aptamers

C Zhu, Z Feng, H Qin, L Chen, M Yan, L Li, F Qu - Talanta, 2024 - Elsevier
Nucleic acid aptamers are oligonucleotide sequences screened by an in vitro methodology
called Systematic Evolution of Ligands by Exponential Enrichment (SELEX). Known as …

Screening, identification, and application of nucleic acid aptamers applied in food safety biosensing

R Liu, F Zhang, Y Sang, I Katouzian, SM Jafari… - Trends in Food Science …, 2022 - Elsevier
Background Nucleic acid aptamers, defined as small functional nucleic acids that can
selectively bind to a specific target, have become one of the main bio-recognition elements …

Diverse high-affinity DNA aptamers for wild-type and B. 1.1. 7 SARS-CoV-2 spike proteins from a pre-structured DNA library

J Li, Z Zhang, J Gu, HD Stacey, JC Ang… - Nucleic acids …, 2021 - academic.oup.com
We performed in vitro selection experiments to identify DNA aptamers for the S1 subunit of
the SARS-CoV-2 spike protein (S1 protein). Using a pool of pre-structured random DNA …

Functional nucleic acids for pathogenic bacteria detection

D Chang, S Zakaria, S Esmaeili Samani… - Accounts of Chemical …, 2021 - ACS Publications
Conspectus Pathogens have long presented a significant threat to human lives, and hence
the rapid detection of infectious pathogens is vital for improving human health. Current …

A Simple Colorimetric Au‐on‐Au Tip Sensor with a New Functional Nucleic Acid Probe for Food‐borne Pathogen Salmonella typhimurium

J Li, S Khan, J Gu, CDM Filipe, TF Didar… - Angewandte …, 2023 - Wiley Online Library
Abstract An Au‐on‐Au tip sensor is developed for the detection of Salmonella typhimurium
(Salmonella), using a new synthetic nucleic acid probe (NAP) as a linker for the …

Research progress of aptasensor technology in the detection of foodborne pathogens

Y He, J Yuan, IM Khan, L Zhang, P Ma, Z Wang - Food Control, 2023 - Elsevier
In recent years, foodborne pathogenic bacteria have gained increasingly serious public
concerns. Therefore, the construction of simple, rapid, effective, and low-cost methods for …

Aptamer-based NanoBioSensors for seafood safety

DJ Sarkar, BK Behera, PK Parida… - Biosensors and …, 2023 - Elsevier
Chemical and biological contaminants are of primary concern in ensuring seafood safety.
Rapid detection of such contaminants is needed to keep us safe from being affected. For …

Progress and challenges in bacterial whole-cell-components aptamer advanced screening and site identification

Y Su, L Zhu, Y Wu, Z Liu, W Xu - TrAC Trends in Analytical Chemistry, 2022 - Elsevier
Since the systematic evolution of ligands by exponential enrichment (SELEX), a process that
has been used extensively in many studies, has yielded mixed results, researchers are …

Discovery and translation of functional nucleic acids for clinically diagnosing infectious diseases: opportunities and challenges

J Li, Z Zhang, R Liu, R Amini, BJ Salena, Y Li - TrAC Trends in Analytical …, 2023 - Elsevier
Functional nucleic acids (FNAs) are short, single-stranded nucleic acids that can be derived
from synthetic nucleic acid libraries using test-tube selection experiments. Due to their …

Aptamer and DNAzyme Based Colorimetric Biosensors for Pathogen Detection

R Liu, J Li, BJ Salena, Y Li - Angewandte Chemie International …, 2025 - Wiley Online Library
The detection of pathogens is critical for preventing and controlling health hazards across
clinical, environmental, and food safety sectors. Functional nucleic acids (FNAs), such as …