Criteria for the translation of radiomics into clinically useful tests

EP Huang, JPB O'Connor, LM McShane… - Nature reviews Clinical …, 2023 - nature.com
Computer-extracted tumour characteristics have been incorporated into medical imaging
computer-aided diagnosis (CAD) algorithms for decades. With the advent of radiomics, an …

Imaging biomarker roadmap for cancer studies

JPB O'connor, EO Aboagye, JE Adams… - Nature reviews Clinical …, 2017 - nature.com
Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs
used daily in oncology include clinical TNM stage, objective response and left ventricular …

Imaging intratumor heterogeneity: role in therapy response, resistance, and clinical outcome

JPB O'Connor, CJ Rose, JC Waterton… - Clinical Cancer …, 2015 - AACR
Tumors exhibit genomic and phenotypic heterogeneity, which has prognostic significance
and may influence response to therapy. Imaging can quantify the spatial variation in …

Models and methods for analyzing DCE‐MRI: A review

F Khalifa, A Soliman, A El‐Baz… - Medical …, 2014 - Wiley Online Library
Purpose: To present a review of most commonly used techniques to analyze dynamic
contrast‐enhanced magnetic resonance imaging (DCE‐MRI), discusses their strengths and …

Clinical development of new drug–radiotherapy combinations

RA Sharma, R Plummer, JK Stock… - Nature reviews Clinical …, 2016 - nature.com
In countries with the best cancer outcomes, approximately 60% of patients receive
radiotherapy as part of their treatment, which is one of the most cost-effective cancer …

[HTML][HTML] Assessment of blood–brain barrier disruption using dynamic contrast-enhanced MRI. A systematic review

AK Heye, RD Culling, MCV Hernández… - NeuroImage: Clinical, 2014 - Elsevier
There is increasing recognition of the importance of blood–brain barrier (BBB) disruption in
aging, dementia, stroke and multiple sclerosis in addition to more commonly-studied …

The transformation of radiation oncology using real-time magnetic resonance guidance: A review

WA Hall, ES Paulson, UA van der Heide… - European Journal of …, 2019 - Elsevier
Radiation therapy (RT) is an essential component of effective cancer care and is used
across nearly all cancer types. The delivery of RT is becoming more precise through rapid …

Eribulin mesylate reduces tumor microenvironment abnormality by vascular remodeling in preclinical human breast cancer models

Y Funahashi, K Okamoto, Y Adachi, T Semba… - Cancer …, 2014 - Wiley Online Library
Eribulin mesylate is a synthetic macrocyclic ketone analog of the marine sponge natural
product halichondrin B and an inhibitor of microtubule dynamics. Some tubulin‐binding …

Ferroptosis MRI for early detection of anticancer drug–induced acute cardiac/kidney injuries

F Zeng, S Nijiati, Y Liu, Q Yang, X Liu, Q Zhang… - Science …, 2023 - science.org
Ferroptosis has been realized in anticancer drug–induced acute cardiac/kidney injuries
(ACI/AKI); however, molecular imaging approach to detect ferroptosis in ACI/AKI is a …

Markers of response for the antiangiogenic agent bevacizumab

D Lambrechts, HJ Lenz, S de Haas… - Journal of Clinical …, 2013 - ascopubs.org
Bevacizumab is the first antiangiogenic therapy proven to slow metastatic disease
progression in patients with cancer. Although it has changed clinical practice, some patients …