Between the 1930s and 50s, evolutionary biologists developed a successful theory of why
organisms age, firmly rooted in population genetic principles. By the 1980s the evolution of …

Discovering the biological basis of aging is one of the greatest remaining challenges for
science. Work on the biology of aging has discovered a range of interventions and pathways …

Suppression of target of rapamycin complex 1 (TORC1) by rapamycin ameliorates aging in
diverse species. S6 kinase (S6K) is an essential mediator, but the mechanisms involved are …

Pleiotropy is the well-established phenomenon of a single gene affecting multiple traits. It
has long played a central role in theoretical, experimental, and clinical research in genetics …

Despite tremendous progress in recent years, our understanding of the evolution of ageing
is still incomplete. A dominant paradigm maintains that ageing evolves due to the competing …

Life-history traits or “fitness components”—such as age and size at maturity, fecundity and
fertility, age-specific rates of survival, and life span—are the major phenotypic determinants …

Intermittent fasting (IF) can improve function and health during aging in laboratory model
organisms, but the mechanisms at work await elucidation. We subjected fruit flies …

Natural antioxidants have recently emerged as a highly exciting and significant topic in anti-
aging research. Diverse organism models present a viable protocol for future research …

Reduced reproduction is associated with increased fat storage and prolonged life span in
multiple organisms, but the underlying regulatory mechanisms remain poorly understood …

High-sugar diets cause thirst, obesity, and metabolic dysregulation, leading to diseases
including type 2 diabetes and shortened lifespan. However, the impact of obesity and water …