Horizons in the evolution of aging
T Flatt, L Partridge - BMC biology, 2018 - Springer
Between the 1930s and 50s, evolutionary biologists developed a successful theory of why
organisms age, firmly rooted in population genetic principles. By the 1980s the evolution of …
organisms age, firmly rooted in population genetic principles. By the 1980s the evolution of …
Genetics of longevity in model organisms: debates and paradigm shifts
D Gems, L Partridge - Annual review of physiology, 2013 - annualreviews.org
Discovering the biological basis of aging is one of the greatest remaining challenges for
science. Work on the biology of aging has discovered a range of interventions and pathways …
science. Work on the biology of aging has discovered a range of interventions and pathways …
[BOOK][B] The nature of nutrition: a unifying framework from animal adaptation to human obesity
SJ Simpson, D Raubenheimer - 2012 - degruyter.com
Nutrition has long been considered more the domain of medicine and agriculture than of the
biological sciences, yet it touches and shapes all aspects of the natural world. The need for …
biological sciences, yet it touches and shapes all aspects of the natural world. The need for …
The many faces of pleiotropy
Pleiotropy is the well-established phenomenon of a single gene affecting multiple traits. It
has long played a central role in theoretical, experimental, and clinical research in genetics …
has long played a central role in theoretical, experimental, and clinical research in genetics …
Evolution of ageing as a tangle of trade-offs: energy versus function
Despite tremendous progress in recent years, our understanding of the evolution of ageing
is still incomplete. A dominant paradigm maintains that ageing evolves due to the competing …
is still incomplete. A dominant paradigm maintains that ageing evolves due to the competing …
Life-History Evolution and the Genetics of Fitness Components in Drosophila melanogaster
T Flatt - Genetics, 2020 - academic.oup.com
Life-history traits or “fitness components”—such as age and size at maturity, fecundity and
fertility, age-specific rates of survival, and life span—are the major phenotypic determinants …
fertility, age-specific rates of survival, and life span—are the major phenotypic determinants …
[HTML][HTML] Reproduction, fat metabolism, and life span: what is the connection?
Reduced reproduction is associated with increased fat storage and prolonged life span in
multiple organisms, but the underlying regulatory mechanisms remain poorly understood …
multiple organisms, but the underlying regulatory mechanisms remain poorly understood …
Short-term, intermittent fasting induces long-lasting gut health and TOR-independent lifespan extension
Intermittent fasting (IF) can improve function and health during aging in laboratory model
organisms, but the mechanisms at work await elucidation. We subjected fruit flies …
organisms, but the mechanisms at work await elucidation. We subjected fruit flies …
Pleiotropic effects of mTOR and autophagy during development and aging
Autophagy as a ubiquitous catabolic process causes degradation of cytoplasmic
components and is generally considered to have beneficial effects on health and lifespan. In …
components and is generally considered to have beneficial effects on health and lifespan. In …
The free‐radical damage theory: accumulating evidence against a simple link of oxidative stress to ageing and lifespan
Recent work on a small European cave salamander (Proteus anguinus) has revealed that it
has exceptional longevity, yet it appears to have unexceptional defences against oxidative …
has exceptional longevity, yet it appears to have unexceptional defences against oxidative …