The molecular mechanisms of copper metabolism and its roles in human diseases

J Chen, Y Jiang, H Shi, Y Peng, X Fan, C Li - Pflügers Archiv-European …, 2020 - Springer
Copper is an essential element in cells; it can act as either a recipient or a donor of
electrons, participating in various reactions. However, an excess of copper ions in cells is …

The molecular and cellular basis of copper dysregulation and its relationship with human pathologies

MT Maung, A Carlson, M Olea‐Flores… - The FASEB …, 2021 - Wiley Online Library
Copper (Cu) is an essential micronutrient required for the activity of redox‐active enzymes
involved in critical metabolic reactions, signaling pathways, and biological functions …

[HTML][HTML] Role of copper in human neurological disorders

V Desai, SG Kaler - The American journal of clinical nutrition, 2008 - Elsevier
Copper is a trace element present in all tissues and is required for cellular respiration,
peptide amidation, neurotransmitter biosynthesis, pigment formation, and connective tissue …

Prion diseases

MD Geschwind - CONTINUUM: Lifelong Learning in Neurology, 2015 - journals.lww.com
Abstract Purpose of Review: This article presents an update on the clinical aspects of human
prion disease, including the wide spectrum of their presentations. Recent Findings: Prion …

[LIBRO][B] Principles of molecular virology

A Cann - 2001 - books.google.com
Principles of Molecular Virology, Third Edition provides an essential introduction to modern
virology in a clear and concise manner. It is a highly enjoyable and readable text with …

[HTML][HTML] Prion disease in dromedary camels, Algeria

B Babelhadj, MA Di Bari, L Pirisinu… - Emerging infectious …, 2018 - ncbi.nlm.nih.gov
Prions cause fatal and transmissible neurodegenerative diseases, including Creutzfeldt-
Jakob disease in humans, scrapie in small ruminants, and bovine spongiform …

Oral transmissibility of prion disease is enhanced by binding to soil particles

CJ Johnson, JA Pedersen, RJ Chappell… - PLoS …, 2007 - journals.plos.org
Soil may serve as an environmental reservoir for prion infectivity and contribute to the
horizontal transmission of prion diseases (transmissible spongiform encephalopathies …

Autophagy regulates exosomal release of prions in neuronal cells

BA Abdulrahman, DH Abdelaziz, HM Schatzl - Journal of Biological …, 2018 - ASBMB
Prions are protein-based infectious agents that autocatalytically convert the cellular prion
protein PrP C to its pathological isoform PrP Sc. Subsequent aggregation and accumulation …

Cellular copper homeostasis: current concepts on its interplay with glutathione homeostasis and its implication in physiology and human diseases

A Bhattacharjee, K Chakraborty, A Shukla - Metallomics, 2017 - academic.oup.com
Copper is a trace element essential for almost all living organisms. But the level of
intracellular copper needs to be tightly regulated. Dysregulation of cellular copper …

Intercommunication between metal ions and amyloidogenic peptides or proteins in protein misfolding disorders

JM Suh, M Kim, J Yoo, J Han, C Paulina… - Coordination Chemistry …, 2023 - Elsevier
The aggregation and accumulation of amyloidogenic peptides and proteins are observed as
pathological features in the brains of patients suffering from neurodegenerative disorders …