The biological and clinical significance of emerging SARS-CoV-2 variants
The past several months have witnessed the emergence of SARS-CoV-2 variants with novel
spike protein mutations that are influencing the epidemiological and clinical aspects of the …
spike protein mutations that are influencing the epidemiological and clinical aspects of the …
Correlates of protection against SARS‐CoV‐2 infection and COVID‐19 disease
Antibodies against epitopes in S1 give the most accurate CoP against infection by the SARS‐
CoV‐2 coronavirus. Measurement of those antibodies by neutralization or binding assays …
CoV‐2 coronavirus. Measurement of those antibodies by neutralization or binding assays …
FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation
SARS-CoV-2 can cause acute respiratory distress and death in some patients. Although
severe COVID-19 is linked to substantial inflammation, how SARS-CoV-2 triggers …
severe COVID-19 is linked to substantial inflammation, how SARS-CoV-2 triggers …
mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant
WF Garcia-Beltran, KJS Denis, A Hoelzemer, EC Lam… - Cell, 2022 - cell.com
Recent surveillance has revealed the emergence of the SARS-CoV-2 Omicron variant (BA.
1/B. 1.1. 529) harboring up to 36 mutations in spike protein, the target of neutralizing …
1/B. 1.1. 529) harboring up to 36 mutations in spike protein, the target of neutralizing …
Vaccination before or after SARS-CoV-2 infection leads to robust humoral response and antibodies that effectively neutralize variants
Current coronavirus disease 2019 (COVID-19) vaccines effectively reduce overall morbidity
and mortality and are vitally important to controlling the pandemic. Individuals who …
and mortality and are vitally important to controlling the pandemic. Individuals who …
Efficacy of covid-19 vaccines in immunocompromised patients: systematic review and meta-analysis
ARYB Lee, SY Wong, LYA Chai, SC Lee, MX Lee… - Bmj, 2022 - bmj.com
Objective To compare the efficacy of covid-19 vaccines between immunocompromised and
immunocompetent people. Design Systematic review and meta-analysis. Data sources …
immunocompetent people. Design Systematic review and meta-analysis. Data sources …
[HTML][HTML] T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individuals
Summary The SARS-CoV-2 Omicron variant (B. 1.1. 529) contains mutations that mediate
escape from antibody responses, although the extent to which these substitutions in spike …
escape from antibody responses, although the extent to which these substitutions in spike …
[HTML][HTML] Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity
Vaccination elicits immune responses capable of potently neutralizing SARS-CoV-2.
However, ongoing surveillance has revealed the emergence of variants harboring mutations …
However, ongoing surveillance has revealed the emergence of variants harboring mutations …
SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery
The host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection can result in prolonged pathologies collectively referred to as post-acute sequalae …
infection can result in prolonged pathologies collectively referred to as post-acute sequalae …
[HTML][HTML] Diverse functional autoantibodies in patients with COVID-19
COVID-19 manifests with a wide spectrum of clinical phenotypes that are characterized by
exaggerated and misdirected host immune responses,,,,–. Although pathological innate …
exaggerated and misdirected host immune responses,,,,–. Although pathological innate …