Increased glucose metabolism and uptake are characteristic of many tumors and used
clinically to diagnose and monitor cancer progression. In addition to cancer cells, the tumor …

The current understanding of lactate extends from its origins as a byproduct of glycolysis to
its role in tumor metabolism, as identified by studies on the Warburg effect. The lactate …

Amino acids are the building blocks of protein synthesis. They are structural elements and
energy sources of cells necessary for normal cell growth, differentiation and function. Amino …

The uptake and metabolism of nutrients support fundamental cellular process from
bioenergetics to biomass production and cell fate regulation. While many studies of cell …

Cancer cells evade T cell-mediated killing through tumour–immune interactions whose
mechanisms are not well understood,. Dendritic cells (DCs), especially type-1 conventional …

Amino acids are basic nutrients for immune cells during organ development, tissue
homeostasis, and the immune response. Regarding metabolic reprogramming in the tumor …

The metabolic stress occurring in the tumor microenvironment (TME) hampers T cell anti-
tumor immunity by disturbing T cell metabolic and epigenetic programs. Recent studies are …

The transformative success of antibodies targeting the PD-1 (programmed death 1)/B7-H1
(B7 homolog 1) pathway (anti-PD therapy) has revolutionized cancer treatment. However …

The metabolically hostile tumour microenvironment imposes barriers to tumour-infiltrating
immune cells and impedes durable clinical remission following immunotherapy. Metabolic …

Amino acid metabolism plays important roles in tumor biology and tumor therapy.
Accumulating evidence has shown that amino acids contribute to tumorigenesis and tumor …