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Neurodevelopment of the association cortices: Patterns, mechanisms, and implications for psychopathology
The human brain undergoes a prolonged period of cortical development that spans multiple
decades. During childhood and adolescence, cortical development progresses from lower …
decades. During childhood and adolescence, cortical development progresses from lower …
Early life adversity shapes neural circuit function during sensitive postnatal developmental periods
Early life adversity (ELA) is a major risk factor for mental illness, but the neurobiological
mechanisms by which ELA increases the risk for future psychopathology are still poorly …
mechanisms by which ELA increases the risk for future psychopathology are still poorly …
Intrinsic activity development unfolds along a sensorimotor–association cortical axis in youth
Animal studies of neurodevelopment have shown that recordings of intrinsic cortical activity
evolve from synchronized and high amplitude to sparse and low amplitude as plasticity …
evolve from synchronized and high amplitude to sparse and low amplitude as plasticity …
Adolescence as a neurobiological critical period for the development of higher-order cognition
The transition from adolescence to adulthood is characterized by improvements in higher-
order cognitive abilities and corresponding refinements of the structure and function of the …
order cognitive abilities and corresponding refinements of the structure and function of the …
Hippocampal GABAergic inhibitory interneurons
In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …
of the total neuronal population; however, their remarkable anatomical and physiological …
[HTML][HTML] Dynamic brains and the changing rules of neuroplasticity: implications for learning and recovery
A growing number of research publications have illustrated the remarkable ability of the
brain to reorganize itself in response to various sensory experiences. A traditional view of …
brain to reorganize itself in response to various sensory experiences. A traditional view of …
VTA GABA neurons at the interface of stress and reward
The ventral tegmental area (VTA) is best known for its robust dopaminergic projections to
forebrain regions and their critical role in regulating reward, motivation, cognition, and …
forebrain regions and their critical role in regulating reward, motivation, cognition, and …
Critical period regulation across multiple timescales
Brain plasticity is dynamically regulated across the life span, peaking during windows of
early life. Typically assessed in the physiological range of milliseconds (real time), these …
early life. Typically assessed in the physiological range of milliseconds (real time), these …
Balancing plasticity/stability across brain development
The potency of the environment to shape brain function changes dramatically across the
lifespan. Neural circuits exhibit profound plasticity during early life and are later stabilized. A …
lifespan. Neural circuits exhibit profound plasticity during early life and are later stabilized. A …
Removal of perineuronal nets unlocks juvenile plasticity through network mechanisms of decreased inhibition and increased gamma activity
Perineuronal nets (PNNs) are extracellular matrix structures mainly enwrap**
parvalbumin-expressing inhibitory neurons. The assembly of PNNs coincides with the end of …
parvalbumin-expressing inhibitory neurons. The assembly of PNNs coincides with the end of …