Circadian rhythms (CR) are a series of endogenous autonomous oscillators generated by
the molecular circadian clock which acting on coordinating internal time with the external …

Mammalian circadian rhythms are controlled by endogenous biological oscillators, including
a master clock located in the hypothalamic suprachiasmatic nuclei (SCN). Since the period …

Activity-dependent transcriptional responses shape cortical function. However, a
comprehensive understanding of the diversity of these responses across the full range of …

The suprachiasmatic nucleus (SCN) is the primary circadian pacemaker in mammals.
Individual SCN neurons in dispersed culture can generate independent circadian …

CREB and its close relatives are now widely accepted as prototypical stimulus-inducible
transcription factors. In many cell types, these factors function as effector molecules that …

The accumulation of adenosine is strongly correlated with the need for sleep and the
detection of sleep pressure is antagonised by caffeine. Caffeine also affects the circadian …

Here we report that synaptic and extrasynaptic NMDA (N-methyl-D-aspartate) receptors
have opposite effects on CREB (cAMP response element binding protein) function, gene …

▪ Abstract Extracellular stimuli elicit changes in gene expression in target cells by activating
intracellular protein kinase cascades that phosphorylate transcription factors within the …

CREB is a transcription factor implicated in the control of adaptive neuronal responses.
Although one function of CREB in neurons is believed to be the regulation of genes whose …

▪ Abstract In mammals, a master circadian “clock” resides in the suprachiasmatic nuclei
(SCN) of the anterior hypothalamus. The SCN clock is composed of multiple, single-cell …