The occurrence of cancer entails a series of genetic mutations that favor uncontrollable
tumor growth. It is believed that various factors collectively contribute to cancer, and there is …

Neuroblastoma (NB) is a pediatric cancer of the sympathetic nervous system and one of the
most common solid tumors in infancy. Amplification of MYCN, copy number alterations …

MYCN is amplified in 20% to 25% of neuroblastoma, and MYCN-amplified neuroblastoma
contributes to a large percent of pediatric cancer–related deaths. Therapy improvements for …

The BCL2 inhibitor venetoclax has been approved to treat different hematological
malignancies. Because there is no common genetic alteration causing resistance to …

In recent years, many studies have shown that histone methylation plays an important role in
maintaining the active and silent state of gene expression in human diseases. The Jumonji …

A neuroblastoma (NB) is a solid paediatric tumour arising from undifferentiated neuronal
cells. Despite the recent advances in disease management and treatment, it remains one of …

Abstract Histone 3 lysine 27 (H3K27) demethylation constitutes an important epigenetic
mechanism of gene activation. It is mediated by the Jumonji C domain-containing lysine …

The lysine‐specific demethylase 6A/UTX (gene name KDM6A) acts as a component of the
COMPASS complex to control gene activation. UTX demethylates H3K27me2/3 at genes …

Aberrant epigenetic modifications are emerging as potent drivers of tumor initiation and
progression. The deregulation of H3K27me3 marks has shown to play an important role in …

Abstract Rationale: Osteosarcoma (OS), the most common type of bone tumor, which
seriously affects the patients' limb function and life quality. OS has a strong tendency of lung …