Lysosomes have been classically considered terminal degradative organelles, but in recent
years they have been found to participate in many other cellular processes, including killing …

Exosomes are a new means of intercellular information exchange that have aroused great
research interest. Long neglected in research, exosomes were deemed nonfunctional …

The discovery of microRNA (miRNA) sorting into extracellular vesicles (EVs) revealed a
novel mode of intercellular communication and uncovered a link between cellular …

Highlights•Endolysosomal organelles are dynamically distributed throughout the
cytoplasm.•Movement of endolysosomal organelles depends on coupling to microtubule …

Late endosomes and lysosomes are dynamic organelles that constantly move and fuse to
acquire cargo from early endosomes, phagosomes and autophagosome. Defects in …

Secretory lysosomes of natural killer (NK) cells, containing perforin and granzymes, are
indispensable for NK-cell cytotoxicity because their release results in the induction of target …

Lysosomal storage diseases (LSDs) comprise a group of inherited monogenic disorders
characterized by lysosomal dysfunctions due to undegraded substrate accumulation. They …

Extracellular vesicles (EV) are a very diverse group of cell-derived vesicles released by
almost all kind of living cells. EV are involved in intercellular exchange, both nearby and …

Lysosomes are an important component of the inner membrane system and participate in
numerous cell biological processes, such as macromolecular degradation, antigen …

Lysosomes are dynamic organelles, which can fuse with a variety of targets and undergo
constant regeneration. They can move along microtubules in a retrograde and anterograde …