Background The introduction of proton pump inhibitors (PPIs) into clinical practice has
revolutionized the management of acid-related diseases. Studies in primary care and …

Upper gastrointestinal bleeding (UGIB) continues to be a common gastrointestinal
emergency that carries significant morbidity and mortality. The epidemiology of UGIB has …

To identify the relationship between proton-pump inhibitors (PPIs) and the risk of fracture, we
conducted an update meta-analysis of observational studies. Results showed that PPI use …

Importance Current guidelines recommend an intravenous bolus dose of a proton pump
inhibitor (PPI) followed by continuous PPI infusion after endoscopic therapy in patients with …

Non-variceal upper gastrointestinal bleeding (UGIB) is defined as bleeding proximal to the
ligament of Treitz in the absence of oesophageal, gastric or duodenal varices. The clinical …

Acute upper and lower gastrointestinal (GI) bleeding may be a potentially life-threatening
event that requires prompt recognition and an early effective management, being …

Background Predictors of worse outcomes (rebleeding, surgery and death) of peptic ulcer
bleeds (PUB s) are essential indicators because of significant morbidity and mortality rates …

Background Tranexamic acid (TXA), a synthetic antifibrinolytic drug, is effective as a
treatment for serious hemorrhage, including bleeding arising from major trauma and post …

Acute upper gastrointestinal haemorrhage due to peptic ulcer bleeding remains an
important cause of emergency presentation and hospital admission. Despite advances in …

The introduction of proton pump inhibitors (PPIs) into clinical practice about thirty years ago
has greatly improved our therapeutic approach to acid-related diseases for their well …