Angiogenesis is an essential process in normal development and in adult physiology, but
can be disrupted in numerous diseases. The concept of targeting angiogenesis for treating …

Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
cancer-related death worldwide. Countless CRC patients undergo disease progression. As …

All organisms growing beyond the oxygen diffusion limit critically depend on a functional
vasculature for survival. Yet blood vessels are far more than passive, uniform conduits for …

Under conditions of hypoxia, most eukaryotic cells can shift their primary metabolic strategy
from predominantly mitochondrial respiration towards increased glycolysis to maintain ATP …

The stromal compartment of the tumor microenvironment consists of a heterogeneous set of
tissue-resident and tumor-infiltrating cells, which are profoundly moulded by cancer cells. An …

Endothelial cells are located at the crucial interface between circulating blood and semi-
solid tissues and have many important roles in maintaining systemic physiological function …

The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …

Diabetic nephropathy (DN) and diabetic retinopathy (DR) are microvascular complications of
diabetes. Microvascular endothelial cells are thought to be the major targets of …

Numerous studies have demonstrated that endothelial cells are capable of undergoing
endothelial to mesenchymal transition (EndMT), a newly recognized type of cellular …

In 2009, it was postulated that endothelial cells (ECs) would only be able to execute the
orders of growth factors if these cells would accordingly adapt their metabolism. Ten years …