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Structural biology of SARS-CoV-2: open the door for novel therapies
W Yan, Y Zheng, X Zeng, B He, W Cheng - Signal Transduction and …, 2022 - nature.com
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative
agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The …
agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The …
[HTML][HTML] SARS-CoV-2-specific immune response and the pathogenesis of COVID-19
E Gusev, A Sarapultsev, L Solomatina… - International journal of …, 2022 - mdpi.com
The review aims to consolidate research findings on the molecular mechanisms and
virulence and pathogenicity characteristics of coronavirus disease (COVID-19) causative …
virulence and pathogenicity characteristics of coronavirus disease (COVID-19) causative …
Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis
F Kabinger, C Stiller, J Schmitzová… - Nature structural & …, 2021 - nature.com
Molnupiravir is an orally available antiviral drug candidate currently in phase III trials for the
treatment of patients with COVID-19. Molnupiravir increases the frequency of viral RNA …
treatment of patients with COVID-19. Molnupiravir increases the frequency of viral RNA …
Structural insights into SARS-CoV-2 proteins
The unprecedented scale of the ongoing COVID-19 pandemic has catalyzed an intense
effort of the global scientific community to unravel different aspects of the disease in a short …
effort of the global scientific community to unravel different aspects of the disease in a short …
Mechanism of SARS-CoV-2 polymerase stalling by remdesivir
Remdesivir is the only FDA-approved drug for the treatment of COVID-19 patients. The
active form of remdesivir acts as a nucleoside analog and inhibits the RNA-dependent RNA …
active form of remdesivir acts as a nucleoside analog and inhibits the RNA-dependent RNA …
COVID-19 drug discovery and treatment options
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused substantial morbidity and …
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused substantial morbidity and …
SARS‐CoV‐2, the pandemic coronavirus: Molecular and structural insights
The outbreak of a novel coronavirus associated with acute respiratory disease, called
COVID‐19, marked the introduction of the third spillover of an animal coronavirus (CoV) to …
COVID‐19, marked the introduction of the third spillover of an animal coronavirus (CoV) to …
Structural characterization of SARS-CoV-2: where we are, and where we need to be
G Mariano, RJ Farthing, SLM Lale-Farjat… - Frontiers in molecular …, 2020 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread in
humans in almost every country, causing the disease COVID-19. Since the start of the …
humans in almost every country, causing the disease COVID-19. Since the start of the …
Structure and function of major SARS-CoV-2 and SARS-CoV proteins
SARS-CoV-2 virus, the causative agent of COVID-19 pandemic, has a genomic organization
consisting of 16 nonstructural proteins (nsps), 4 structural proteins, and 9 accessory …
consisting of 16 nonstructural proteins (nsps), 4 structural proteins, and 9 accessory …
[HTML][HTML] Extremely potent human monoclonal antibodies from COVID-19 convalescent patients
Human monoclonal antibodies are safe, preventive, and therapeutic tools that can be rapidly
developed to help restore the massive health and economic disruption caused by the …
developed to help restore the massive health and economic disruption caused by the …