The mammary gland is a compound, branched tubuloalveolar structure and a major
characteristic of mammals. The mammary gland has evolved from epidermal apocrine …

Interactions between cancer cells and their surroundings can trigger essential signaling
cues that determine cell fate and influence the evolution of the malignant phenotype. As the …

Treatment-persistent residual tumors impede curative cancer therapy. To understand this
cancer cell state we generated models of treatment persistence that simulate the residual …

Most patients with advanced triple-negative breast cancer (TNBC) develop drug resistance.
MYC and MCL1 are frequently co-amplified in drug-resistant TNBC after neoadjuvant …

Tumour-initiating cells (TICs) are responsible for metastatic dissemination and clinical
relapse in a variety of cancers,. Analogies between TICs and normal tissue stem cells have …

Previous studies have suggested that breast cancer stem cells (BCSCs) mediate metastasis,
are resistant to radiation and chemotherapy, and contribute to relapse. Although several …

Recently, organoid technology has been used to generate a large repository of breast
cancer organoids. Here we present an extensive evaluation of the ability of organoid culture …

Abstract FOXM1 (Forkhead box M1) is an oncogenic transcription factor that is greatly
upregulated in breast cancer and many other cancers where it promotes tumorigenesis, and …

Regulatory networks orchestrated by key transcription factors (TFs) have been proposed to
play a central role in the determination of stem cell states. However, the master …

Breast cancer is a heterogeneous disease in terms of histology, therapeutic response,
dissemination patterns to distant sites, and patient outcomes. Global gene expression …