IL-6 is involved both in immune responses and in inflammation, hematopoiesis, bone
metabolism and embryonic development. IL-6 plays roles in chronic inflammation (closely …

Abstract Interleukin 6 (IL-6) has a broad effect on cells of the immune system and those not
of the immune system and often displays hormone-like characteristics that affect homeostatic …

The environment, diet, microbiota and body's metabolism shape complex biological
processes in health and disease. However, our understanding of the molecular pathways …

IL-17 cytokine family members have diverse biological functions, promoting protective
immunity against many pathogens but also driving inflammatory pathology during infection …

Infectious diseases are a leading cause of death worldwide. Sepsis is a severe clinical
syndrome related to the host response to infection. The severity of infections is due to an …

Metabolism is a major regulator of immune cell function, but it remains difficult to study the
metabolic status of individual cells. Here, we present Compass, an algorithm to characterize …

T lymphocytes, the major effector cells in cellular immunity, produce cytokines in immune
responses to mediate inflammation and regulate other types of immune cells. Work in the …

Interleukin-1 (IL-1) is a central mediator of innate immunity and inflammation. The IL-1 family
includes seven ligands with agonist activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL …

The transforming growth factor-β (TGF-β) is the prototype of the TGF-β family of growth and
differentiation factors, which is encoded by 33 genes in mammals and comprises homo-and …

Macrophages display remarkable plasticity and can change their physiology in response to
environmental cues. These changes can give rise to different populations of cells with …