Neurodegenerative diseases (NDs) including Alzheimer's disease, Parkinson's disease,
amyotrophic lateral sclerosis, and Huntington's disease are incurable and affect millions of …

Synthetic biology is a research field that combines the investigative nature of biology with
the constructive nature of engineering. Efforts in synthetic biology have largely focused on …

James A. Shapiro proposes an important new paradigm for understanding biological
evolution, the core organizing principle of biology. Shapiro introduces crucial new molecular …

Novel cellular behaviors and characteristics can be obtained by coupling engineered gene
networks to the cell's natural regulatory circuitry through appropriately designed input and …

The homeostatic framework has dominated our understanding of cellular physiology. We
question whether homeostasis alone adequately explains microbial responses to …

Synthetic gene circuits are designed to program new biological behaviour, dynamics and
logic control. For all but the simplest synthetic phenotypes, this requires a structured …

Biological networks, such as those describing gene regulation, signal transduction, and
neural synapses, are representations of large-scale dynamic systems. Discovery of …

What can we learn from the collective dynamics of a complex network about its interaction
topology? Taking the perspective from nonlinear dynamics, we briefly review recent …

Directed evolution is a form of artificial selection that has been used for decades to find
biomolecules and organisms with new or enhanced functional traits. Directed evolution can …

Protein sequestration occurs when an active protein is sequestered by a repressor into an
inactive complex. Using mathematical and computational modeling, we show how this …