Parkinson's families project: a UK-wide study of early onset and familial Parkinson's disease
Abstract The Parkinson's Families Project is a UK-wide study aimed at identifying genetic
variation associated with familial and early-onset Parkinson's disease (PD). We recruited …
variation associated with familial and early-onset Parkinson's disease (PD). We recruited …
Insights into Ancestral Diversity in Parkinsons Disease Risk: A Comparative Assessment of Polygenic Risk Scores
Objectives To evaluate and compare different polygenic risk score (PRS) models in
predicting Parkinsons disease (PD) across diverse ancestries, focusing on identifying the …
predicting Parkinsons disease (PD) across diverse ancestries, focusing on identifying the …
Large-scale genetic characterization of Parkinson's disease in the African and African admixed populations
F Akcimen, K Paquette, PW Crea, P Saffie-Awad… - medRxiv, 2025 - medrxiv.org
Elucidating the genetic contributions to Parkinson′ s disease (PD) etiology across diverse
ancestries is a critical priority in the development of targeted therapies in a global context …
ancestries is a critical priority in the development of targeted therapies in a global context …
[HTML][HTML] The LRRK2 p. L1795F variant causes Parkinson's disease in the European population
Pathogenic variants in the LRRK2 gene represent the most common cause of autosomal
dominant Parkinson's disease (PD) worldwide. We identified the LRRK2 p. L1795F variant …
dominant Parkinson's disease (PD) worldwide. We identified the LRRK2 p. L1795F variant …
Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease
E Eubanks, K VanderSleen, J Mody, N Patel… - …, 2024 - pmc.ncbi.nlm.nih.gov
Alpha-synuclein (αSyn) is an intrinsically disordered protein that accumulates in the brains
of patients with Parkinson's disease and forms intraneuronal inclusions called Lewy Bodies …
of patients with Parkinson's disease and forms intraneuronal inclusions called Lewy Bodies …
The Role of Genomic-Informed Risk Assessments in Predicting Dementia Outcomes
SJ Andrews, C Jonson, B Fulton-Howard… - medRxiv, 2024 - pmc.ncbi.nlm.nih.gov
Importance: By integrating genetic and clinical risk factors into genomic-informed dementia
risk reports, healthcare providers can offer patients detailed risk profiles to facilitate …
risk reports, healthcare providers can offer patients detailed risk profiles to facilitate …
CNV-Finder: Streamlining Copy Number Variation Discovery
Copy Number Variations (CNVs) play pivotal roles in the etiology of complex diseases and
are variable across diverse populations. Understanding the association between CNVs and …
are variable across diverse populations. Understanding the association between CNVs and …
Biobank-scale characterization of Alzheimer's disease and related dementias identifies potential disease-causing variants, risk factors, and genetic modifiers across …
Alzheimer's disease and related dementias (AD/ADRDs) pose a significant global public
health challenge, underscored by the intricate interplay of genetic and environmental factors …
health challenge, underscored by the intricate interplay of genetic and environmental factors …
Parkinson's Families Project: a UK-wide study of early onset and familial Parkinson's disease
The Parkinson′ s Families Project is a UK-wide study aimed at identifying genetic variation
associated with familial and early-onset Parkinson′ s disease (PD). We recruited …
associated with familial and early-onset Parkinson′ s disease (PD). We recruited …
Cluster Buster: A Machine Learning Algorithm for Genoty** SNPs from Raw Data
Genoty** single nucleotide polymorphisms (SNPs) is fundamental to disease research, as
researchers seek to establish links between genetic variation and disease. Although …
researchers seek to establish links between genetic variation and disease. Although …