Non-coding RNA networks in cancer

E Anastasiadou, LS Jacob, FJ Slack - Nature Reviews Cancer, 2018‏ - nature.com
Thousands of unique non-coding RNA (ncRNA) sequences exist within cells. Work from the
past decade has altered our perception of ncRNAs from'junk'transcriptional products to …

Circulating microRNAs in cancer: potential and challenge

M Cui, H Wang, X Yao, D Zhang, Y **e, R Cui… - Frontiers in …, 2019‏ - frontiersin.org
MicroRNAs (miRNAs) are endogenous non-coding small RNA molecules that can be
secreted into the circulation and exist in remarkably stable forms. Like intercellular miRNAs …

A network-biology perspective of microRNA function and dysfunction in cancer

CP Bracken, HS Scott, GJ Goodall - Nature Reviews Genetics, 2016‏ - nature.com
MicroRNAs (miRNAs) participate in most aspects of cellular differentiation and homeostasis,
and consequently have roles in many pathologies, including cancer. These small non …

OncomiR or tumor suppressor? The duplicity of microRNAs in cancer

AA Svoronos, DM Engelman, FJ Slack - Cancer research, 2016‏ - aacrjournals.org
MicroRNAs (miRNA) are short, noncoding RNAs whose dysregulation has been implicated
in most, if not all, cancers. They regulate gene expression by suppressing mRNA translation …

MicroRNA biogenesis pathways in cancer

S Lin, RI Gregory - Nature reviews cancer, 2015‏ - nature.com
MicroRNAs (miRNAs) are critical regulators of gene expression. Amplification and
overexpression of individual'oncomiRs' or genetic loss of tumour suppressor miRNAs are …

A model for RAS mutation patterns in cancers: finding the sweet spot

S Li, A Balmain, CM Counter - Nature Reviews Cancer, 2018‏ - nature.com
The three RAS genes—HRAS, NRAS and KRAS—are collectively mutated in one-third of
human cancers, where they act as prototypic oncogenes. Interestingly, there are rather …

MicroRNAs in cancer: biomarkers, functions and therapy

J Hayes, PP Peruzzi, S Lawler - Trends in molecular medicine, 2014‏ - cell.com
The emergence of microRNAs has been one of the defining developments in cancer biology
over the past decade, and the explosion of knowledge in this area has brought forward new …

Overview of microRNA biology

AM Mohr, JL Mott - Seminars in liver disease, 2015‏ - thieme-connect.com
In considering an overview of microRNA biology, it is useful to consider microRNAs as a part
of cellular communication. At the simplest level, microRNAs act to decrease the expression …

MicroRNA (miRNA) in cancer

KB Reddy - Cancer cell international, 2015‏ - Springer
In recent years, there has been a tremendous and growing interest among researchers to
investigate the role of mircoRNA (miRNA) in normal cellular as well as in disease processes …

miRNAs as potential game-changers in head and neck cancer: Future clinical and medicinal uses

HA El-Mahdy, AM Mohamadin, AI Abulsoud… - … -Research and Practice, 2023‏ - Elsevier
Head and neck cancers (HNCs) are a group of heterogeneous tumors formed most
frequently from epithelial cells of the larynx, lips, oropharynx, nasopharynx, and mouth …