Is target-based drug discovery efficient? Discovery and “off-target” mechanisms of all drugs

A Sadri - Journal of medicinal chemistry, 2023 - ACS Publications
Target-based drug discovery is the dominant paradigm of drug discovery; however, a
comprehensive evaluation of its real-world efficiency is lacking. Here, a manual systematic …

Persistent organic pollutants: The trade-off between potential risks and sustainable remediation methods

D Negrete-Bolagay, C Zamora-Ledezma… - Journal of environmental …, 2021 - Elsevier
Abstract Persistent Organic Pollutants (POPs) have become a very serious issue for the
environment because of their toxicity, resistance to conventional degradation mechanisms …

[HTML][HTML] Analysis of the biochemical and histopathological impact of a mild dose of commercial malathion on Channa punctatus (Bloch) fish

S Bharti, F Rasool - Toxicology Reports, 2021 - Elsevier
The intensive application of pesticides without proper disposal management has led their
excess residues to reach the neighbouring aquatic ecosystem and its inhabitants mainly …

Tap** the role of microbial biosurfactants in pesticide remediation: an eco-friendly approach for environmental sustainability

A Raj, A Kumar, JF Dames - Frontiers in Microbiology, 2021 - frontiersin.org
Pesticides are used indiscriminately all over the world to protect crops from pests and
pathogens. If they are used in excess, they contaminate the soil and water bodies and …

A global systematic review, meta-analysis and health risk assessment on the quantity of Malathion, Diazinon and Chlorpyrifos in Vegetables

M Kermani, M Dowlati, M Gholami, HR Sobhi, A Azari… - Chemosphere, 2021 - Elsevier
It is widely believed that an increasing trend in the production and consumption of
vegetables has led to a dramatic rise in the use of pesticides potentially threatening the …

Organophosphate Insecticide Malathion Induces Alzheimer's Disease-Like Cognitive Impairment in Mice: Evidence of the Microbiota-Gut-Brain Axis

J Cui, S **ao, Y Cao, Y Zhang, J Yang… - Environmental …, 2024 - ACS Publications
Evidence suggests that exposure to organophosphate pesticides increases the risk of
neurodegenerative diseases, but the mechanisms remain unclear. This study investigated …

[HTML][HTML] Electrochemical evaluation of fenitrothion organophosphate pesticide in food samples: Novel tetra trifluoromethyl carboxamide zinc (II) macrocyclic complex …

O Nagaraja, H Nagarajappa, A Pandith… - Composites Part B …, 2024 - Elsevier
This study presents the development of a groundbreaking electrochemical sensor for
detecting fenitrothion (FNT) using a multi-walled carbon nanotubes (MWCNTs) and a newly …

Biodegradation strategies of veterinary medicines in the environment: Enzymatic degradation

X Xu, X Lin, W Ma, M Huo, X Tian, H Wang… - Science of the Total …, 2024 - Elsevier
One Health closely integrates healthy farming, human medicine, and environmental
ecology. Due to the ecotoxicity and risk of transmission of drug resistance, veterinary …

Spent coffee grounds-derived carbon material as an effective adsorbent for removing multiple contaminants from wastewater: A comprehensive kinetic, isotherm, and …

V Milanković, T Tasić, S Brković, N Potkonjak… - Journal of Water …, 2024 - Elsevier
Environmental contamination from various industrial sources poses a significant global
concern, demanding effective remediation strategies. This study investigates the efficacy of …

Structural design of nanosize-metal–organic framework-based sensors for detection of organophosphorus pesticides in food and water samples: current challenges …

SN Nangare, SR Patil, AG Patil, ZG Khan… - Journal of Nanostructure …, 2021 - Springer
Organophosphorus pesticide (OPP) is regarded as an important food-chain and
environmental contaminant that causes primary acute toxicity and numerous severe health …