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Is target-based drug discovery efficient? Discovery and “off-target” mechanisms of all drugs
A Sadri - Journal of medicinal chemistry, 2023 - ACS Publications
Target-based drug discovery is the dominant paradigm of drug discovery; however, a
comprehensive evaluation of its real-world efficiency is lacking. Here, a manual systematic …
comprehensive evaluation of its real-world efficiency is lacking. Here, a manual systematic …
Persistent organic pollutants: The trade-off between potential risks and sustainable remediation methods
D Negrete-Bolagay, C Zamora-Ledezma… - Journal of environmental …, 2021 - Elsevier
Abstract Persistent Organic Pollutants (POPs) have become a very serious issue for the
environment because of their toxicity, resistance to conventional degradation mechanisms …
environment because of their toxicity, resistance to conventional degradation mechanisms …
[HTML][HTML] Analysis of the biochemical and histopathological impact of a mild dose of commercial malathion on Channa punctatus (Bloch) fish
The intensive application of pesticides without proper disposal management has led their
excess residues to reach the neighbouring aquatic ecosystem and its inhabitants mainly …
excess residues to reach the neighbouring aquatic ecosystem and its inhabitants mainly …
Tap** the role of microbial biosurfactants in pesticide remediation: an eco-friendly approach for environmental sustainability
Pesticides are used indiscriminately all over the world to protect crops from pests and
pathogens. If they are used in excess, they contaminate the soil and water bodies and …
pathogens. If they are used in excess, they contaminate the soil and water bodies and …
A global systematic review, meta-analysis and health risk assessment on the quantity of Malathion, Diazinon and Chlorpyrifos in Vegetables
It is widely believed that an increasing trend in the production and consumption of
vegetables has led to a dramatic rise in the use of pesticides potentially threatening the …
vegetables has led to a dramatic rise in the use of pesticides potentially threatening the …
Organophosphate Insecticide Malathion Induces Alzheimer's Disease-Like Cognitive Impairment in Mice: Evidence of the Microbiota-Gut-Brain Axis
J Cui, S **ao, Y Cao, Y Zhang, J Yang… - Environmental …, 2024 - ACS Publications
Evidence suggests that exposure to organophosphate pesticides increases the risk of
neurodegenerative diseases, but the mechanisms remain unclear. This study investigated …
neurodegenerative diseases, but the mechanisms remain unclear. This study investigated …
[HTML][HTML] Electrochemical evaluation of fenitrothion organophosphate pesticide in food samples: Novel tetra trifluoromethyl carboxamide zinc (II) macrocyclic complex …
This study presents the development of a groundbreaking electrochemical sensor for
detecting fenitrothion (FNT) using a multi-walled carbon nanotubes (MWCNTs) and a newly …
detecting fenitrothion (FNT) using a multi-walled carbon nanotubes (MWCNTs) and a newly …
Biodegradation strategies of veterinary medicines in the environment: Enzymatic degradation
X Xu, X Lin, W Ma, M Huo, X Tian, H Wang… - Science of the Total …, 2024 - Elsevier
One Health closely integrates healthy farming, human medicine, and environmental
ecology. Due to the ecotoxicity and risk of transmission of drug resistance, veterinary …
ecology. Due to the ecotoxicity and risk of transmission of drug resistance, veterinary …
Spent coffee grounds-derived carbon material as an effective adsorbent for removing multiple contaminants from wastewater: A comprehensive kinetic, isotherm, and …
Environmental contamination from various industrial sources poses a significant global
concern, demanding effective remediation strategies. This study investigates the efficacy of …
concern, demanding effective remediation strategies. This study investigates the efficacy of …
Structural design of nanosize-metal–organic framework-based sensors for detection of organophosphorus pesticides in food and water samples: current challenges …
SN Nangare, SR Patil, AG Patil, ZG Khan… - Journal of Nanostructure …, 2021 - Springer
Organophosphorus pesticide (OPP) is regarded as an important food-chain and
environmental contaminant that causes primary acute toxicity and numerous severe health …
environmental contaminant that causes primary acute toxicity and numerous severe health …