The SH-SY5Y cell line in Parkinson's disease research: a systematic review

H **coy, B Wieringa, GJM Martens - Molecular neurodegeneration, 2017 - Springer
Parkinson's disease (PD) is a devastating and highly prevalent neurodegenerative disease
for which only symptomatic treatment is available. In order to develop a truly effective …

2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy

D Zhang, J Li, F Wang, J Hu, S Wang, Y Sun - Cancer letters, 2014 - Elsevier
Cancer cells are characterized by altered glucose metabolism known as the Warburg effect
in which aerobic glycolysis is increased. Glucose is converted to lactate even under …

Acetate production from glucose and coupling to mitochondrial metabolism in mammals

X Liu, DE Cooper, AA Cluntun, MO Warmoes, S Zhao… - Cell, 2018 - cell.com
Acetate is a major nutrient that supports acetyl-coenzyme A (Ac-CoA) metabolism and thus
lipogenesis and protein acetylation. However, its source is unclear. Here, we report that …

[HTML][HTML] A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth

JC Schell, KA Olson, L Jiang, AJ Hawkins… - Molecular cell, 2014 - cell.com
Cancer cells are typically subject to profound metabolic alterations, including the Warburg
effect wherein cancer cells oxidize a decreased fraction of the pyruvate generated from …

Neuroprotective and therapeutic strategies against Parkinson's disease: recent perspectives

S Sarkar, J Raymick, S Imam - International journal of molecular sciences, 2016 - mdpi.com
Parkinsonism is a progressive motor disease that affects 1.5 million Americans and is the
second most common neurodegenerative disease after Alzheimer's. Typical …

Ketogenic diets enhance oxidative stress and radio-chemo-therapy responses in lung cancer xenografts

BG Allen, SK Bhatia, JM Buatti, KE Brandt… - Clinical Cancer …, 2013 - aacrjournals.org
Purpose: Ketogenic diets are high in fat and low in carbohydrates as well as protein which
forces cells to rely on lipid oxidation and mitochondrial respiration rather than glycolysis for …

Mitochondrial dysfunction leads to cortical under-connectivity and cognitive impairment

A Fernandez, DW Meechan, BA Karpinski, EM Paronett… - Neuron, 2019 - cell.com
Under-connectivity between cerebral cortical association areas may underlie cognitive
deficits in neurodevelopmental disorders, including the 22q11. 2 deletion syndrome …

Molecular targeting of hypoxia in radiotherapy

S Rey, L Schito, M Koritzinsky, BG Wouters - Advanced Drug Delivery …, 2017 - Elsevier
Hypoxia (low O 2) is an essential microenvironmental driver of phenotypic diversity in
human solid cancers. Hypoxic cancer cells hijack evolutionarily conserved, O 2-sensitive …

Recent progress on magnetic nanoparticles for magnetic hyperthermia

L Kafrouni, O Savadogo - Progress in biomaterials, 2016 - Springer
Recent advances in nanomaterials science contributed to develop new micro-and nano-
devices as potential diagnostic and therapeutic tools in the field of oncology. The synthesis …

[HTML][HTML] The influence of cell type and culture medium on determining cancer selectivity of cold atmospheric plasma treatment

E Biscop, A Lin, W Van Boxem, J Van Loenhout… - Cancers, 2019 - mdpi.com
Increasing the selectivity of cancer treatments is attractive, as it has the potential to reduce
side-effects of therapy. Cold atmospheric plasma (CAP) is a novel cancer treatment that …