Background In the phase III CheckMate 743 study (NCT02899299), first-line nivolumab plus
ipilimumab significantly improved overall survival (OS) versus chemotherapy in patients with …

Osteosarcoma (OS) is the most common type of primary malignant bone tumor. The high-
throughput sequencing technology has shown potential abilities to illuminate the pathogenic …

There are numerous ways of portraying cancer complexity based on combining multiple
types of data. A common approach involves develo** signatures from gene expression …

Background: The tumor microenvironment (TME) mainly comprises tumor cells and tumor-
infiltrating immune cells mixed with stromal components. Latestresearch hasdisplayed that …

The risk prognosis model is a statistical model that uses a set of features to predict whether
an individual will develop a specific disease or clinical outcome. It can be used in clinical …

Cancer immunotherapy is a promising therapeutic approach, but the prognostic value of
immune-related genes in osteosarcoma (OS) is unknown. Here, Target-OS RNA-seq data …

Osteosarcoma is the most prevalent bone tumor in pediatric patients. Neoadjuvant
chemotherapy has improved osteosarcoma patient survival, however the 5-year survival rate …

Osteosarcoma (OS) is the most common bone-derived tumor, and chemoresistance is a
pivotal factor in the poor prognosis of patients with OS. Ferroptosis, as an emerging modality …

Osteosarcoma, one of the most common primary malignancies in children and adolescents,
has the primary characteristics of a poor prognosis and high rate of metastasis. This study …

Background Previous evidence has shown that apoptosis performs integral functions in the
tumorigenesis and development of various tumors. Therefore, this study aimed to establish a …