BACKGROUND: Closed-loop control of anesthesia involves continual adjustment of drug
infusion rates according to measured clinical effect. The NeuroSENSE monitor provides an …

Abstract Background and Objective: Many methodologies have been proposed for the
control of total intravenous anesthesia in general surgery, as this yields a reduced stress for …

This paper describes the design and evaluation of a controller for multi-input single-output
(MISO) propofol-remifentanil anesthesia, guided by feedback from a measure of depth-of …

This paper proposes a constrained control scheme for the control of the depth of hypnosis in
clinical anesthesia. The proposed scheme guarantees overdosing prevention while taking …

Closed-loop anesthesia drug delivery systems can reduce the effect of inter-patient
variability, minimize variability in desired clinical effects, and ultimately improve patient …

This paper studies application of different constrained control concepts for the control of
Depth of Hypnosis (DOH) in closed-loop anesthesia to guarantee patient safety, while …

The benefits of closed-loop control of anesthesia in terms of drug usage, robustness to inter-
patient variability and postoperative outcomes have been demonstrated in a number of …

Over the last decade, anesthesia research community witnessed numerous advances in
controllers and their implementation platforms to control the depth of anesthesia (DoA) in a …

This paper deals with a new strategy for the control of anesthesia taking into account the
saturation of the actuator and the target interval tolerated for the depth of anesthesia during …

Medical drug infusion problems pose a combination of challenges such as nonlinearities
from physiological models, model uncertainty due to inter-and intra-patient variability, as …