The role of silicon in drug discovery: a review
JL Panayides, DL Riley, F Hasenmaile… - RSC Medicinal …, 2024 - pubs.rsc.org
This review aims to highlight the role of silicon in drug discovery. Silicon and carbon are
often regarded as being similar with silicon located directly beneath carbon in the same …
often regarded as being similar with silicon located directly beneath carbon in the same …
Development of a poly (vinyl alcohol)/lysine electrospun membrane-based drug delivery system for improved skin regeneration
RS Sequeira, SP Miguel, CSD Cabral… - International journal of …, 2019 - Elsevier
Nanofiber-based wound dressings are currently being explored as delivery systems of
different biomolecules for avoiding skin infections as well as improve/accelerate the healing …
different biomolecules for avoiding skin infections as well as improve/accelerate the healing …
[HTML][HTML] Isatin-based ibuprofen and mefenamic acid Schiff base derivatives as dual inhibitors against urease and α–glucosidase: In vitro, in silico and cytotoxicity …
S Daud, M Saadullah, M Fakhar-e-Alam… - Journal of Saudi …, 2024 - Elsevier
Abstract α-Glucosidase and urease inhibitors have emerged as crucial for develo**
therapeutic drugs targeting diabetes and gastrointestinal disorders. This study reports on …
therapeutic drugs targeting diabetes and gastrointestinal disorders. This study reports on …
Co-delivery of azithromycin and ibuprofen by ROS-responsive polymer nanoparticles synergistically attenuates the acute lung injury
W Muhammad, Y Zhang, J Zhu, J **e, S Wang… - Biomaterials …, 2023 - Elsevier
Bacterial infection causes lung inflammation and recruitment of several inflammatory factors
that may result in acute lung injury (ALI). During bacterial infection, reactive oxygen species …
that may result in acute lung injury (ALI). During bacterial infection, reactive oxygen species …
A Computational Method for the Binding Mode Prediction of COX-1 and COX-2 Inhibitors: Analyzing the Union of Coxibs, Oxicams, Propionic and Acetic Acids
E Bello-Vargas, MA Leyva-Peralta, Z Gómez-Sandoval… - Pharmaceuticals, 2023 - mdpi.com
Among the biological targets extensively investigated to improve inflammation and chronic
inflammatory conditions, cyclooxygenase enzymes (COXs) occupy a prominent position …
inflammatory conditions, cyclooxygenase enzymes (COXs) occupy a prominent position …
Antiproliferative and antiinflammatory coxib–combretastatin hybrids suppress cell cycle progression and induce apoptosis of MCF7 breast cancer cells
QA Ngo, THN Thi, MQ Pham, D Delfino, TT Do - Molecular Diversity, 2021 - Springer
In our study, some newly synthesized aryl-substituted pyrazole derivatives mimicking cis-
diphenylethylene scaffold of two apoptotic inducing agents celecoxib and combretastatin A …
diphenylethylene scaffold of two apoptotic inducing agents celecoxib and combretastatin A …
Analysis of ibuprofen and its main metabolites in roots, shoots, and seeds of cowpea (Vigna unguiculata L. Walp) using liquid chromatography-quadrupole time-of …
A liquid chromatography quadruple time-of-flight mass spectrometry (LC–QqTOF-MS/MS)
method was developed for simultaneous quantitative analysis of ibuprofen (IBU), 1-and 2 …
method was developed for simultaneous quantitative analysis of ibuprofen (IBU), 1-and 2 …
Synthesis and characterization of new monothiooxalamides containing pyridine nuclei with promising antiproliferative and antioxidant activity
CE Macías-Hernández, MM Romero-Chávez… - Journal of Molecular …, 2022 - Elsevier
New family monothiooxalamides containing pyridine moiety were synthesized. The
structures of monothiooxalamides were confirmed by one-dimension NMR experiments 1 H …
structures of monothiooxalamides were confirmed by one-dimension NMR experiments 1 H …
Development of ibuprofen dry suspensions by hot melt extrusion: Characterization, physical stability and pharmacokinetic studies
Z Yang, Y Hu, G Tang, M Dong, Q Liu, X Lin - Journal of Drug Delivery …, 2019 - Elsevier
The aim of this study was to develop ibuprofen dry suspensions using hot melt extrusion to
improve the in vivo performance of ibuprofen. Ibuprofen was melt-extruded into solid …
improve the in vivo performance of ibuprofen. Ibuprofen was melt-extruded into solid …
[HTML][HTML] Synthesis and toxicity of monothiooxalamides against human red blood cells, brine shrimp (Artemia salina), and fruit fly (Drosophila melanogaster)
MM Romero-Chávez, CE Macías-Hernández… - Heliyon, 2024 - cell.com
A new family of monothiooxalamides derived from 2-aminobenzimidazole was synthesized,
and their structures were confirmed by 1 H and 13 C one-dimensional and 2D NMR …
and their structures were confirmed by 1 H and 13 C one-dimensional and 2D NMR …