Molecular physiology of Arc/Arg3. 1: The oligomeric state hypothesis of synaptic plasticity

MS Eriksen, CR Bramham - Acta Physiologica, 2022 - Wiley Online Library
The immediate early gene, Arc, is a pivotal regulator of synaptic plasticity, memory, and
cognitive flexibility. But what is Arc protein? How does it work? Inside the neuron, Arc is a …

Arc protein, a remnant of ancient retrovirus, forms virus-like particles, which are abundantly generated by neurons during epileptic seizures, and affects epileptic …

DA Sibarov, V Tsytsarev, A Volnova… - Frontiers in …, 2023 - frontiersin.org
A product of the immediate early gene Arc (Activity-regulated cytoskeleton-associated
protein or Arc protein) of retroviral ancestry resides in the genome of all tetrapods for millions …

A cryo-ET survey of microtubules and intracellular compartments in mammalian axons

HE Foster, C Ventura Santos, AP Carter - Journal of Cell Biology, 2021 - rupress.org
The neuronal axon is packed with cytoskeletal filaments, membranes, and organelles, many
of which move between the cell body and axon tip. Here, we used cryo-electron tomography …

Astragaloside IV mediates radiation-induced neuronal damage through activation of BDNF-TrkB signaling

X Liu, Y Ding, C Jiang, Y **n, X Ma, M Xu, Q Wang… - Phytomedicine, 2024 - Elsevier
Background Electromagnetic radiation is relevant to human life, and radiation can trigger
neurodegenerative diseases by altering the function of the central nervous system through …

Extracellular Vesicle-Mediated Neuron–Glia Communications in the Central Nervous System

T Ikezu, Y Yang, C Verderio… - Journal of …, 2024 - jneurosci.org
Communication between neurons and glia significantly influences the development
maturation, plasticity, and disease progressions of the nervous system. As a new signaling …

Mechanisms and functions of activity-regulated cytoskeleton-associated protein in synaptic plasticity

Y Chen, X Wang, B **ao, Z Luo, H Long - Molecular Neurobiology, 2023 - Springer
Activity-regulated cytoskeleton-associated protein (Arc) is one of the most important
regulators of cognitive functions in the brain regions. As a hub protein, Arc plays different …

RNA‐binding proteins in pain

PR Smith, ZT Campbell - Wiley Interdisciplinary Reviews: RNA, 2024 - Wiley Online Library
RNAs are meticulously controlled by proteins. Through direct and indirect associations,
every facet in the brief life of an mRNA is subject to regulation. R NA‐b inding p roteins …

A compendium of validated pain genes

E Wistrom, R Chase, PR Smith… - WIREs Mechanisms of …, 2022 - Wiley Online Library
The development of novel pain therapeutics hinges on the identification and rigorous
validation of potential targets. Model organisms provide a means to test the involvement of …

Astragaloside IV ameliorates radiation‐induced nerve cell damage by activating the BDNF/TrkB signaling pathway

X Liu, Y Ding, C Jiang, X Ma, Y **n, Y Li… - Phytotherapy …, 2023 - Wiley Online Library
Radiation can induce nerve cell damage. Synapse connectivity and functionality are thought
to be the essential foundation of all cognitive functions. Therefore, treating and preventing …

The RNA-binding protein HuR is integral to the function of nociceptors in mice and humans

N Kunder, JB de la Peña, TF Lou, R Chase… - Journal of …, 2022 - jneurosci.org
HuR is an RNA-binding protein implicated in RNA processing, stability, and translation.
Previously, we examined protein synthesis in dorsal root ganglion (DRG) neurons treated …