Pyrazole derivatives, as a class of heterocyclic compounds, possess unique chemical
structures that confer them with a broad spectrum of pharmacological activities. They have …

Bringing to a halt the cell cycle in mitosis and interfering with its normal progression is one of
the most successful anti-cancer strategies used nowadays. Classically, several kinds of anti …

Background Lung adenocarcinoma (LUAD) is challenging in clinical practice due to the poor
understanding of molecular mechanisms and limited therapeutic targets. Herein, the work …

The mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway is frequently
reported to be hyperactivated in hepatocellular carcinoma (HCC) and contributes to HCC …

Many clinical trials of kinesin spindle protein (KSP) inhibitors have failed due to issues such
as high toxicity and a short circulation half-life in vivo. To address the limitations of current …

Microtubules (MTs) are essential for many cellular processes including establishment of cell
shape and polarity, chromosome segregation, vesicle transport, and nuclear positioning …

One concept of improving anticancer effects of conventional platinum‐based antitumor
drugs consists of conjugating these compounds with other biologically (antitumor) active …